How is 5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) typically synthesized?

5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) is typically synthesized via a multi-step process involving the methylation of nicotinic acid followed by reduction of the acetyl group to an amino group. Commonly, methyl nitrate is used as the methylating agent, and sodium borohydride is employed as a reducing agent. The overall yield is around 70-80%, and the reaction is carried out under mild acidic conditions.