3,5-Dichloropyridazine

Basic Information

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CAS Number

1837-55-4

Molecular Formula

C4H2Cl2N2

Molecular Weight

148.98 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

60.0 to 64.0 deg-C

Boiling Point

280.8°C at 760 mmHg

Density

1.493

Flash Point

150.5°C

Refractive Index

1.559

SMILES

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C1=C(C=NN=C1Cl)Cl

InChI

InChI=1S/C4H2Cl2N2/c5-3-1-4(6)8-7-2-3/h1-2H

InChIKey

JZSAUQMXKHBZEO-UHFFFAOYSA-N

LogP

1.7833999999999999

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

78.4

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

3,5-Dichloro-pyridazine
AB61136
PYRIDAZINE, 3,5-DICHLORO-
AM84639
JZSAUQMXKHBZEO-UHFFFAOYSA-N
AKOS006305099
AS-18922
DTXSID20601477
EN300-96061
D4447
SCHEMBL400310
3,5-Dichloropyridazine
A4069
CS-D0778
Z1198278268
3,5-Dichlor-pyridazin
1837-55-4
MFCD10698048
FT-0646966
SY019550
AC-25155
CHEBI:194771
BCP22319
PYRIDAZINE,3,5-DICHLORO
3,5-dichloropyridazine

MDL Number

MFCD10698048

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 3,5-Dichloropyridazine (CAS: 1837-55-4)?

3,5-Dichloropyridazine (CAS: 1837-55-4) is a crystalline solid with a molecular weight of approximately 171.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is relatively stable under normal conditions but can react with bases to form pyridazine derivatives. It is an important intermediate in organic synthesis and has limited reactivity with common laboratory reagents.

How is 3,5-Dichloropyridazine (CAS: 1837-55-4) typically synthesized?

3,5-Dichloropyridazine is typically synthesized through the electrochemical oxidation of 2,6-dichloropyridine. This process involves the use of a platinum electrode in a water-based electrolyte. Alternatively, it can be prepared by the reaction of 2,6-dichloropyridine with phosphorus oxychloride in the presence of a Lewis acid catalyst. The yields are usually around 85-90%, and the method is known for its good selectivity and ease of operation.

What industries use 3,5-Dichloropyridazine (CAS: 1837-55-4)?

3,5-Dichloropyridazine (CAS: 1837-55-4) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It also finds applications in the production of organic semiconductors and sensors due to its unique electronic properties. Additionally, it is utilized in the polymer industry for the development of specialized polymers with improved properties.

What precautions should be taken when handling 3,5-Dichloropyridazine (CAS: 1837-55-4)?

When handling 3,5-Dichloropyridazine (CAS: 1837-55-4), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure that all operations are conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, immediately clean up with caution and use appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions to ensure safe laboratory practices.