2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine | CAS No. 1825352-86-0

2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine

Basic Information

CAS Number

1825352-86-0

Molecular Formula

C14H20BN3O2

Molecular Weight

273.15 g/mol

AD

Basic Physical Properties

B1(OC(C(O1)(C)C)(C)C)c2cc(c3nc(cn3n2)C)C

InChI

InChI=1S/C14H20BN3O2/c1-9-7-11(17-18-8-10(2)16-12(9)18)15-19-13(3,4)14(5,6)20-15/h7-8H,1-6H3

InChIKey

UCBLAGDTLLXGNA-UHFFFAOYSA-N

LogP

1.6453399999999998

Topological Polar Surface Area

48.650000000000006 Ų

Hydrogen Bond Donor/Acceptor

0 / 5

Complexity

375

Synonyms & References

English

  • 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine
  • TQR0467
  • 2,8-Dimethylimidazo[1,2-b]pyridazine-6-boronic Acid Pinacol Ester
  • SY277227
  • CC1=CN2N=C(C=C(C)C2=N1)B1OC(C)(C)C(C)(C)O1
  • 2,8-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine

MDL Number

MFCD3155643

FAQ

What are the physical and chemical properties of 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine (CAS: 1825352-86-0)?

2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine is a crystalline compound with a molecular weight of approximately 412.48 g/mol. It has low solubility in water but is soluble in organic solvents like DMSO. The compound is known for its reactivity in organoboron coupling reactions, which makes it useful in synthetic chemistry.

How is 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine (CAS: 1825352-86-0) typically synthesized?

2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine is usually synthesized via a Pd-catalyzed coupling reaction of a boronic acid with a brominated or chlorinated imidazo[1,2-b]pyridazine derivative. The reaction involves the use of a palladium catalyst, a base, and a ligand to achieve high yields and selectivity.

What industries use 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine (CAS: 1825352-86-0)?

This compound is primarily used in the pharmaceutical and organic synthesis industries due to its reactivity in organoboron coupling reactions. It can also be applied in polymer synthesis and as a building block in the development of new materials.

What precautions should be taken when handling 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine (CAS: 1825352-86-0)?

When handling 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. Store the compound in a dry place and use a fume hood during synthesis. In case of spill, follow the manufacturer's safety data sheet (SDS) for proper disposal and clean-up procedures.

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