[(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol

Basic Information

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CAS Number

1821773-67-4

Molecular Formula

C13H19NO2

Molecular Weight

221.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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C[C@@H]1CN(C[C@@H](O1)CO)Cc2ccccc2

InChI

InChI=1S/C13H19NO2/c1-11-7-14(9-13(10-15)16-11)8-12-5-3-2-4-6-12/h2-6,11,13,15H,7-10H2,1H3/t11-,13-/m1/s1

InChIKey

VGPHTTKTZQGSHW-DGCLKSJQSA-N

LogP

1.2682

Topological Polar Surface Area

32.7 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

204

Synonyms & References

English

((2R,6R)-4-benzyl-6-methylmorpholin-2-yl)methanol
[(2R,6R)-4-benzyl-6-methylmorpholin-2-yl]methanol
FCH2789537
AX8239050

MDL Number

MFCD19443208

FAQ

What are the physical and chemical properties of [(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol (CAS: 1821773-67-4)?

The compound [(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol (CAS: 1821773-67-4) is a white crystalline solid with a molecular weight of approximately 275.31 g/mol. It has a moderate solubility in common organic solvents such as methanol and ethanol but is poorly soluble in water. Chemically, it exhibits good reactivity toward nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from strong oxidizing agents.

How is [(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol (CAS: 1821773-67-4) typically synthesized?

[(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol (CAS: 1821773-67-4) can be synthesized through a multi-step process involving the preparation of 2-benzyl-6-methylmorpholine, followed by reaction with benzyl alcohol. This involves a Sonogashira coupling and a Grignard reaction. The final product is obtained with good yield and selectivity, making it a useful intermediate in organic synthesis.

What industries use [(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol (CAS: 1821773-67-4)?

[(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol (CAS: 1821773-67-4) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of drugs. It is also utilized in the production of polymers and in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling [(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol (CAS: 1821773-67-4)?

When handling [(2R,6R)-4-Benzyl-6-methyl-2-morpholinyl]methanol (CAS: 1821773-67-4), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be stored in a cool, dry place away from heat sources and oxidizing agents. In case of a spill, clean it up using appropriate absorbent materials and follow the Safety Data Sheet (SDS) for further instructions. Always ensure proper ventilation and use a fume hood when necessary.