1-(Aminomethyl)cyclobutanol

Basic Information

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CAS Number

180205-28-1

Molecular Formula

C5H11NO

Molecular Weight

101.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Boiling Point

176.0±13.0 ºC (760 Torr),

Flash Point

60.2±19.8 ºC,

SMILES

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NCC1(O)CCC1

InChI

InChI=1S/C5H11NO/c6-4-5(7)2-1-3-5/h7H,1-4,6H2

InChIKey

QMRGVILFWQUZKR-UHFFFAOYSA-N

LogP

-0.13990000000000036

Topological Polar Surface Area

46.25 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

68.5

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1-(Aminomethyl)cyclobutanol
1-(aminomethyl)cyclobutan-1-ol
1-Aminomethyl-cyclobutanol
1-(aminomethyl)cyclobutanol hydrochloride
1-(Aminomethyl)cyclobutanol1-(Aminomethyl)cyclobutanol
Cyclobutanol, 1-(aminomethyl)-
1-(Aminomethyl);cyclobutanol
QMRGVILFWQUZKR-UHFFFAOYSA-N
SB15565
VZ21001
AB0022946
W3913
ST24026939
1-Aminomethyl-Cyclobutanol P-Toluenes

MDL Number

MFCD11040537

Customs Code

2922199090

FAQ

What are the physical and chemical properties of 1-(Aminomethyl)cyclobutanol (CAS: 180205-28-1)?

1-(Aminomethyl)cyclobutanol (CAS: 180205-28-1) is a colorless liquid with a pungent odor. It has a molecular weight of approximately 104.13 g/mol and a boiling point of 177°C. This compound is moderately soluble in water and organic solvents. It is reactive towards nucleophiles and can undergo substitution reactions. It is generally stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

How is 1-(Aminomethyl)cyclobutanol (CAS: 180205-28-1) typically synthesized?

1-(Aminomethyl)cyclobutanol can be synthesized via a multi-step process involving the condensation of cyclobutanone with ammonia followed by reduction. Commonly used catalysts include palladium on carbon. The synthetic route typically achieves a yield of around 70-80%, with good selectivity and purity. This reaction should be conducted under nitrogen to prevent oxidation.

What industries use 1-(Aminomethyl)cyclobutanol (CAS: 180205-28-1)?

1-(Aminomethyl)cyclobutanol (CAS: 180205-28-1) is used in the pharmaceutical industry for the synthesis of certain drugs. It is also applied in the polymer industry as a monomer for the production of special polymers with unique properties. Additionally, it is utilized in the semiconductor industry for the fabrication of sensors and in the sensor industry for developing gas detection devices.

What precautions should be taken when handling 1-(Aminomethyl)cyclobutanol (CAS: 180205-28-1)?

When handling 1-(Aminomethyl)cyclobutanol (CAS: 180205-28-1), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Laboratory work involving this compound should be conducted in a well-ventilated area or a fume hood. Spills should be handled immediately by sweeping into a container and disposing of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage.