(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid | CAS No. 180064-38-4

(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid

Basic Information

CAS Number

180064-38-4

Molecular Formula

C9H12N2O7P2

Molecular Weight

322.15 g/mol

AD

Basic Physical Properties

Density

1.97

Refractive Index

1.744

C1=CC2=NC=C(N2C=C1)CC(O)(P(=O)(O)O)P(=O)(O)O

InChI

InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)

InChIKey

VMMKGHQPQIEGSQ-UHFFFAOYSA-N

LogP

-0.12170000000000014

Topological Polar Surface Area

152.59 Ų

Hydrogen Bond Donor/Acceptor

5 / 9

Complexity

439

Safety Information

View Safety Information

GHS Hazard Pictograms

H302H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

  • AS-73348
  • ONO 5920
  • (1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosphonoethyl)phosphonic acid
  • BDBM25308
  • (1-hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)bis(phosphonic acid)
  • Minodronic acid [INN]
  • NSC 725590
  • MINODRONIC ACID [MART.]
  • AKOS015856182
  • [1-hydroxy-2-(3-imidazo[1,2-a]pyridinyl)-1-phosphonoethyl]phosphonic acid
  • (1-hydroxy-2-imidazo[1,2-a]pyridin-3-yl-1-phosphonoethyl)phosphonic acid
  • NS00069233
  • YM-529
  • YM529
  • MINODRONIC ACID [MI]
  • UNII-40SGR63TGL
  • Phosphonic acid, P,P'-(1-hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bis-
  • YH-529
  • (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid
  • bisphosphonate, 57
  • Minodronic acidMinodronic acid
  • CHEMBL319144
  • s5057
  • CAS-180064-38-4
  • C73434
  • C9H12N2O7P2
  • VMMKGHQPQIEGSQ-UHFFFAOYSA-N
  • M0N
  • (1-Hydroxy-2-Imidazo[1,2-A]pyridin-3-Ylethane-1,1-Diyl)bis(Phosphonic Acid)
  • NSC-725590
  • Q2823280

MDL Number

MFCD00890772

Customs Code

2933990090

FAQ

What are the physical and chemical properties of (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid (CAS: 180064-38-4)?

(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid is a diphosphonic acid derivative with a molecular weight of approximately 395.34 g/mol. It crystallizes in a solid form and is moderately soluble in water. This compound shows good stability under neutral and slightly acidic conditions but is reactive towards metal ions, making it useful in chelation therapy and other industrial applications.

How is (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid (CAS: 180064-38-4) typically synthesized?

(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid is synthesized through a multi-step process involving the reaction of 1-hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane with phosphorus oxychloride or a similar reagent. The reaction is typically conducted under anhydrous conditions with the use of a suitable catalyst to enhance selectivity and yield. Detailed synthesis protocols can be found in the literature.

What industries use (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid (CAS: 180064-38-4)?

(1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid is utilized in the pharmaceutical industry for its chelating properties, making it a valuable reagent in drug development. It is also used in the polymer industry for improving material properties and in the semiconductor industry for etching processes. Its sensing capabilities make it suitable for analytical applications as well.

What precautions should be taken when handling (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid (CAS: 180064-38-4)?

When handling (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid, it is essential to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be stored in a cool, dry place, away from direct sunlight and moisture. In case of spillage, immediate clean-up should be conducted using appropriate materials, and the spill area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.

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