Amoxicillin EP Impurity L

Basic Information

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CAS Number

1789703-32-7

Molecular Formula

C24H29N5O7S2

Molecular Weight

563.66 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

White to Pale Yellow

Melting Point

Boiling Point

996.5±65.0 °C(Predicted)

Density

1.60±0.1 g/cm3(Predicted)

Flash Point

556.5±34.3 °C

Solubility

Methanol (Slightly), Water (Slightly)

Vapor Pressure

0.0±0.3 mmHg at 25°C

SMILES

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CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](c3ccc(cc3)O)N)C(=O)N[C@H]4[C@@H]5N(C4=O)[C@H](C(S5)(C)C)C(=O)O)C

InChI

InChI=1S/C24H29N5O7S2/c1-23(2)14(17(32)27-13-19(34)29-15(22(35)36)24(3,4)38-21(13)29)28-18(33)12(20(28)37-23)26-16(31)11(25)9-5-7-10(30)8-6-9/h5-8,11-15,20-21,30H,25H2,1-4H3,(H,26,31)(H,27,32)(H,35,36)/t11-,12-,13-,14+,15+,20-,21-/m1/s1

InChIKey

VUPFQJZTIWDYHG-SHJTWVOLSA-N

LogP

-0.4291999999999969

pKa

2.44±0.50(Predicted)

Topological Polar Surface Area

182.36999999999998 Å²

Hydrogen Bond Donor/Acceptor

6 / 12

Safety Information

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Hazard Statement

Stability

Very Hygroscopic

Synonyms & References

English

Amoxicillin EP Impurity L
(2S,5R,6R)-6-[[(2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl] amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbonyl] amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Amoxicillin Impurity 11（EP Impurity L）
Amoxicillin impurity 10/Amoxicillin EP Impurity L
Amoxicillin Related Compound L
6-APA Amoxicillin Amide
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
(2S,5R,6R)-6-[[[(2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
APA Amoxicillin Amide
(2S,5R,6R)-6-((2S,5R,6R)-6-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

FAQ

What regulatory guidelines apply to Amoxicillin EP Impurity L (CAS: 1789703-32-7)?

Amoxicillin EP Impurity L (CAS: 1789703-32-7) is subject to various regulatory guidelines, including GHS for hazardous chemicals, REACH for the registration, evaluation, authorization, and restriction of chemicals in the European Union, and FDA/EPA requirements for pharmaceutical and environmental safety. Manufacturers must ensure compliance with these regulations to ensure the safety and efficacy of the product.

Are there alternatives to Amoxicillin EP Impurity L (CAS: 1789703-32-7) in synthesis?

In the synthesis of Amoxicillin, alternatives to Amoxicillin EP Impurity L (CAS: 1789703-32-7) include using other amoxicillin-related compounds or optimizing the synthesis process to minimize the formation of this impurity. Common alternative reagents include benzylpenicillin and other β-lactam antibiotics, which can serve as starting materials or intermediates.

What is the market or research trend for Amoxicillin EP Impurity L (CAS: 1789703-32-7)?

The market for Amoxicillin EP Impurity L (CAS: 1789703-32-7) is closely tied to the broader demand for amoxicillin and antibiotics. Research trends focus on improving synthesis methods to reduce this impurity, as well as developing new antibiotics to address increasing antibiotic resistance. The impurity's presence is a concern for regulatory compliance and product quality, driving continuous efforts to minimize its occurrence.

How should waste containing Amoxicillin EP Impurity L (CAS: 1789703-32-7) be handled?

Waste containing Amoxicillin EP Impurity L (CAS: 1789703-32-7) should be collected in appropriate containers and handled according to local regulations. Incineration is a common method for disposal, but professional waste disposal services are recommended to ensure compliance with environmental protection standards. Proper labeling and documentation are essential to prevent environmental contamination and ensure safety during disposal.