Ambrisentan Impurity 8

Basic Information

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CAS Number

178306-52-0

Molecular Formula

C16H16O4

Molecular Weight

272.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

430.3±45.0°C at 760 mmHg

SMILES

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COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(C(=O)O)O

InChI

InChI=1S/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)/t14-/m1/s1

InChIKey

RQJWOLFMWKZKCJ-CQSZACIVSA-N

LogP

2.0220999999999996

Topological Polar Surface Area

66.76 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

298

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

(s)-2-hydroxy-3-methoxy-3,3-diphenyl propionic acid
AMY1844
FD7216
(s)-2-hydroxyl -3-methoxy-3,3-diphenylpropanoic acid
RQJWOLFMWKZKCJ-CQSZACIVSA-N
CS-0150662
BYC8HKB4JS
DTXSID20572219
BENZENEPROPANOIC ACID,A-HYDROXY-B-METHOXY-B-PHENYL-,(AS)-
AS-19559
SCHEMBL570658
BENZENEPROPANOIC ACID, .ALPHA.-HYDROXY-.BETA.-METHOXY-.BETA.-PHENYL-, (.ALPHA.S)-
MFCD11113284
AKOS015907675
Benzenepropanoic acid, alpha-hydroxy-beta-methoxy-beta-phenyl-, (alphaS)-
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoicacid
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid
Benzenepropanoic acid, ?-hydroxy-?-methoxy-?-phenyl-, (S)-; (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid; 2S-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid
178306-52-0
(2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
H1568
UNII-BYC8HKB4JS
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid
BCP04673
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
(S)-2-Hydroxyl -3-Methoxy-3,3-diphenylpropanoic acid
Benzenepropanoic acid, a-hydroxy-b-methoxy-b-phenyl-, (aS)-
ALST-3
S-2-Hydroxy-3-methoxy-3
3-diphenylpropanoic acid
AMbrisentan InterMediate

MDL Number

MFCD11113284

FAQ

What is Ambrisentan Impurity 8 (CAS: 178306-52-0)?

Ambrisentan Impurity 8 is a byproduct of the synthesis of Ambrisentan, a phosphodiesterase type 5 inhibitor used to treat pulmonary arterial hypertension. It does not have a defined chemical formula or properties as it is a mixture of impurities.

What are the main uses of Ambrisentan Impurity 8 (CAS: 178306-52-0)?

Ambrisentan Impurity 8 is primarily used for quality control and impurity profiling in the pharmaceutical industry to ensure the purity of Ambrisentan. It is not used for any therapeutic purposes.

Is Ambrisentan Impurity 8 (CAS: 178306-52-0) safe?

Ambrisentan Impurity 8 is generally considered safe when handled under proper laboratory conditions. However, it is important to follow standard safety protocols, including wearing appropriate personal protective equipment and handling in a well-ventilated area.

How should Ambrisentan Impurity 8 (CAS: 178306-52-0) be stored?

Ambrisentan Impurity 8 should be stored in a cool, dry place, away from direct sunlight and moisture. It is recommended to store it in a tightly sealed container to prevent degradation. The exact storage temperature and conditions may vary depending on the specific properties of the impurity, so it is advisable to refer to the material safety data sheet (MSDS) for detailed storage instructions.