Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (1:1)

Basic Information

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CAS Number

176977-85-8

Molecular Formula

C7H7Cl2NO2

Molecular Weight

208.04 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

136-138

Boiling Point

298℃ at 760 mmHg

SMILES

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COC(=O)C1=NC=CC(=C1)Cl.Cl

InChI

InChI=1S/C7H6ClNO2.ClH/c1-11-7(10)6-4-5(8)2-3-9-6;/h2-4H,1H3;1H

InChIKey

PAGFSBPYVNFHAS-UHFFFAOYSA-N

LogP

1.9434

Topological Polar Surface Area

39.19 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

151

Safety Information

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GHS Hazard Pictograms

H319

Hazard Statement

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

methyl 4-chloropyridine-2-carboxylate HCl salt
FS-4002
Methyl 4-chloropyridine-2-carboxylate--hydrogen chloride (1/1)
DTXSID80586514
176977-85-8
Methyl 4-chloropyridine-2-carboxylate hydrochloride
A3930
FT-0652358
methyl 4-chloropyridine-2-carboxylate;hydrochloride
PB18698
AM20070186
4-Chloropyridine-2-carboxylic acid methyl ester hydrochloride
Methyl 4-Chloropicolinate Hydrochloride Salt
Methyl 4-Chloro-2-Pyridinecarboxylate HCl
AKOS015845730
METHYL 4-CHLOROPICOLINATE HCL
METHYL 4-CHLOROPICOLINATE, HCL
J-522336
methyl 4-chloropyridine-2-carboxylate HCI salt
4-chloro-pyridine-2-carboxylic acid methyl ester HCl salt
4-Chloro-pyridine-2-carboxylic acid methyl ester hydrochloride, AldrichCPR
MFCD05864729
4-Chloro-pyridine-2-carboxylic acid methyl ester hydrochloride
METHYL 4-CHLOROPYRIDINE-2-CARBOXYLATE HCL
Methyl 4-chloro-2-pyridinecarboxylate hydrochloride
CS-W015242
PAGFSBPYVNFHAS-UHFFFAOYSA-N
Discontinued See M294457
AB3942
4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER HCL
Methyl 4-chloropicolinate hydrochloride

MDL Number

MFCD05864729

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (CAS: 176977-85-8)?

Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (CAS: 176977-85-8) is a crystalline solid with a molecular weight of approximately 239.6 g/mol. It has a solubility of 0.2 g/L in water and is slightly soluble in ethanol. The compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a dry place to avoid hydrolysis.

How is Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (CAS: 176977-85-8) typically synthesized?

Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (CAS: 176977-85-8) is typically synthesized by reacting methyl 4-chloro-2-pyridinecarboxylate with hydrochloric acid. The reaction is conducted in a solvent such as dichloromethane or ethyl acetate, and the yield is usually around 85%. The use of a phase transfer catalyst can improve selectivity and yield.

What industries use Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (CAS: 176977-85-8)?

Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (CAS: 176977-85-8) is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for the modification of polymers, and in the sensor industry for the development of gas sensors. Additionally, it has potential uses in semiconductor manufacturing for etching processes.

What precautions should be taken when handling Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (CAS: 176977-85-8)?

When handling Methyl 4-chloro-2-pyridinecarboxylate hydrochloride (CAS: 176977-85-8), it is important to use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area, preferably in a fume hood. Spills should be cleaned up using an appropriate absorbent material and the area should be flushed with water. Safety data sheets (SDS) should always be consulted for detailed safety information.