1-oxa-8-azaspiro[4.5]decane

Basic Information

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CAS Number

176-92-1

Molecular Formula

C8H15NO

Molecular Weight

141.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

229 ºC

Flash Point

85 ºC

SMILES

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C1CC2(CCNCC2)OC1

InChI

InChI=1S/C8H15NO/c1-2-8(10-7-1)3-5-9-6-4-8/h9H,1-7H2

InChIKey

KVYOWXUQJLOCIA-UHFFFAOYSA-N

LogP

0.919

Topological Polar Surface Area

21.259999999999998 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

118

Synonyms & References

English

1-oxa-8-aza-spiro[4.5]decane
176-92-1
DTXSID20620325
SB20120
MFCD11035889
AM86021
KVYOWXUQJLOCIA-UHFFFAOYSA-N
EN300-1086908
1-Oxa-8-azaspiro[4.5]decane
SCHEMBL255188
AKOS006336240
BB 0261411
F13279
1-Oxa-8-aza-spiro <4,5> decan
1-oxa-8-azaspiro[4.5]decane

MDL Number

MFCD11035889

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 1-oxa-8-azaspiro[4.5]decane (CAS: 176-92-1)?

1-Oxa-8-azaspiro[4.5]decane is a cyclic amine with a molecular weight of approximately 194.25 g/mol. It is a colorless solid that is moderately soluble in common organic solvents like methanol and chloroform. Chemically, it can react with acids and bases, and its reactivity is influenced by its basic nature.

How is 1-oxa-8-azaspiro[4.5]decane (CAS: 176-92-1) typically synthesized?

1-Oxa-8-azaspiro[4.5]decane is commonly synthesized via the condensation of 1,8-diamino-4,5-dioxo-3,6-diaza-1,4,7,10-tetraoxacyclododecane with a reducing agent like sodium borohydride. This method provides a yield of about 80% and the reaction is conducted in an aqueous medium.

What industries use 1-oxa-8-azaspiro[4.5]decane (CAS: 176-92-1)?

1-Oxa-8-azaspiro[4.5]decane finds applications in pharmaceuticals, where it serves as a precursor for various drug molecules, and in polymers, where it is used as a monomer for synthesizing biodegradable polymers. It is also utilized in sensors and certain semiconductor applications.

What precautions should be taken when handling 1-oxa-8-azaspiro[4.5]decane (CAS: 176-92-1)?

When handling 1-oxa-8-azaspiro[4.5]decane, it is important to wear appropriate personal protective equipment (PPE), including gloves and goggles. Work should be conducted in a well-ventilated area or a fume hood. In case of spillage, it should be cleaned up immediately using appropriate materials and procedures, and the incident should be reported to the appropriate safety officer. Always refer to the Safety Data Sheet (SDS) for specific handling instructions.