1-oxa-8-azaspiro[4.5]decane(CAS: 176-92-1)

1-Oxa-8-azaspiro[4.5]decane is a cyclic amine with a molecular weight of approximately 194.25 g/mol. It is a colorless solid that is moderately soluble in common organic solvents like methanol and chloroform. Chemically, it can react with acids and bases, and its reactivity is influenced by its basic nature.

1-Oxa-8-azaspiro[4.5]decane is commonly synthesized via the condensation of 1,8-diamino-4,5-dioxo-3,6-diaza-1,4,7,10-tetraoxacyclododecane with a reducing agent like sodium borohydride. This method provides a yield of about 80% and the reaction is conducted in an aqueous medium.

1-Oxa-8-azaspiro[4.5]decane finds applications in pharmaceuticals, where it serves as a precursor for various drug molecules, and in polymers, where it is used as a monomer for synthesizing biodegradable polymers. It is also utilized in sensors and certain semiconductor applications.

When handling 1-oxa-8-azaspiro[4.5]decane, it is important to wear appropriate personal protective equipment (PPE), including gloves and goggles. Work should be conducted in a well-ventilated area or a fume hood. In case of spillage, it should be cleaned up immediately using appropriate materials and procedures, and the incident should be reported to the appropriate safety officer. Always refer to the Safety Data Sheet (SDS) for specific handling instructions.