Lamivudine Salicylate

Basic Information

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CAS Number

173522-96-8

Molecular Formula

C15H15N3O5S

Molecular Weight

349.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

138-143°C

SMILES

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C1C(OC(S1)COC(=O)C2=CC=CC=C2O)N3C=CC(=NC3=O)N

InChI

InChI=1S/C15H15N3O5S/c16-11-5-6-18(15(21)17-11)12-8-24-13(23-12)7-22-14(20)9-3-1-2-4-10(9)19/h1-6,12-13,19H,7-8H2,(H2,16,17,21)/t12-,13+/m0/s1

InChIKey

MUAWHSKZVSAWMH-QWHCGFSZSA-N

LogP

1.07750

Complexity

567

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

[(2R,5S)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl 2-hydroxybenzoate
C15H15N3O5S
A881761
AKOS015999206
173522-96-8
((2R,5S)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl2-hydroxybenzoate
DTXSID00620964
SCHEMBL1389107
[(2R,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-1,3-oxathiolan-2-yl]methyl 2-hydroxybenzoate
((2R,5S)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl 2-hydroxybenzoate
(2r-cis)-4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1h)-pyrimidinone 2-hydroxybenzoate
2R-(HYDROXYMETHYL)-5(S)-CYTOSIN-1-YL-[1,3]-OXATHIOLANE SALICYCIC ACID SALT ( LAMIVUDINE SALICYLATE)
lamivudine salicylate
Lamivudine Salicylate (CTS)
2r-(Hydroxymethyl)-5(S)-Cytosin-1-Yl-1,3-Oxathiolanesalicycic Acid Salt
2R-(HYDROXYMETHYL)-5(S)-CYTOSIN-1-YL-[1,3]-OXATHIOLANE SALICYLIC ACID SALT
(2R, 5S) -2-(Hydroxymethyl)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane salicylate
2R-(hydroxymethyl)-5(S)-cytosin-lyl-1,3-oxothiolane salicylic acid salt (Lamivudine Salicylate)
2R-(HYDROXYMETHYL)-5(S)-CYTOSIN-1-YL-1,3-OXATHIOLANESALICYCIC ACID SALT (LAMIVUDINE SALICYLATE)

MDL Number

MFCD09751000

FAQ

What are the physical and chemical properties of Lamivudine Salicylate (CAS: 173522-96-8)?

Lamivudine Salicylate (CAS: 173522-96-8) is a crystalline compound with a molecular weight of approximately 317.25 g/mol. It has a solubility of about 10 mg/mL in water and is slightly soluble in ethanol. Chemically, it exhibits good stability in neutral and slightly acidic solutions but is less stable in strongly acidic or basic conditions. It reacts readily with bases to form its conjugate base, and it can be oxidized under certain conditions.

How is Lamivudine Salicylate (CAS: 173522-96-8) typically synthesized?

Lamivudine Salicylate (CAS: 173522-96-8) is synthesized through a multi-step process involving the salicylate esterification of lamivudine. The first step involves the preparation of lamivudine, which is then reacted with salicylic acid in the presence of a catalyst such as triethylamine. The reaction mixture is then purified through recrystallization to obtain the desired product with high yield and selectivity.

What industries use Lamivudine Salicylate (CAS: 173522-96-8)?

Lamivudine Salicylate (CAS: 173522-96-8) is primarily used in the pharmaceutical industry, particularly in the formulation of antiviral medications. It is also used in some polymer and sensor applications where its chemical properties are utilized.

What precautions should be taken when handling Lamivudine Salicylate (CAS: 173522-96-8)?

When handling Lamivudine Salicylate (CAS: 173522-96-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood to prevent inhalation of potential fumes. Spills should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.