Cosyntropin | CAS No. 16960-16-0

Cosyntropin

Basic Information

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CAS Number

16960-16-0

Molecular Formula

C136H210N40O31S

Molecular Weight

2933.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Water Solubility

Soluble in water

SMILES

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CC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC8=CNC=N8)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC9=CC=C(C=C9)O)NC(=O)C(CO)N

InChI

InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1

InChIKey

ZOEFCCMDUURGSE-SQKVDDBVSA-N

LogP

-7.964489999999952

Topological Polar Surface Area

1158.72 Å²

Hydrogen Bond Donor/Acceptor

50 / 71

Complexity

6500

Synonyms & References

English

beta(1-24)-Corticotropin
1-24-ACTH
SCHEMBL33366
CORTICOTROPIN TETRACOSAPEPTIDE
CHEBI:3901
alpha(1-24)-Corticotropin
TETRACOSACTIDE (MART.)
COSYNTROPIN (USP MONOGRAPH)
TETRACOSACTIDE (EP MONOGRAPH)
Corticotropin (1-24)-Peptide
Tetracosactrin
COSYNTROPIN
HS-2001
Actholain
CHEMBL2103784
Corticotropin S
tetracosactrin zinc
AC-8933
VICOTROPE
AKOS015994630
16960-16-0
BDBM50017180
Cortrosyn
AMY25377
DTXCID501437057
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
Tetracosactide Acetate (ACTH 1-24)
Cortrosinta
ACTH(1-24)
H01AA02
beta(1-24)-ACTH

MDL Number

MFCD00167476

FAQ

What are the physical and chemical properties of Cosyntropin (CAS: 16960-16-0)?

Cosyntropin is a synthetic hormone with a molecular weight of approximately 342.43 g/mol. It is a white to off-white crystalline powder with a melting point of 180-185°C. Cosyntropin is poorly soluble in water but soluble in organic solvents. It is stable under normal storage conditions but degrades under alkaline or acidic conditions. It is not reactive with common chemicals but should be handled with care to prevent contamination.

How is Cosyntropin (CAS: 16960-16-0) typically synthesized?

Cosyntropin is synthesized through a multi-step chemical process involving amino acid coupling and acylation. The key steps include the coupling of amino acids to form the peptide backbone, followed by side-chain modifications. The synthesis typically involves the use of coupling reagents like HATU or EDC, and the reaction is carried out in organic solvents like DMF. The yield is usually between 60-80%, and the product is purified by HPLC or chromatography.

What industries use Cosyntropin (CAS: 16960-16-0)?

Cosyntropin is primarily used in the pharmaceutical industry, particularly in the treatment of adrenal insufficiency, as a diagnostic tool for diagnosing primary or secondary adrenal insufficiency, and in the treatment of hypotension. It is also used in research for its anti-inflammatory and immunomodulatory properties. Additionally, it has applications in veterinary medicine for the treatment of hypoadrenocorticism in animals.

What precautions should be taken when handling Cosyntropin (CAS: 16960-16-0)?

When handling Cosyntropin, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from light and moisture. Fume hoods should be used when mixing or dissolving the compound. In case of a spill, immediately clean up with water and dispose of the waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.