(~2~H_8_)Tetrahydrofuran

Basic Information

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CAS Number

1693-74-9

Molecular Formula

C4D8O

Molecular Weight

80.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

−106 °C

Boiling Point

65-66 °C

Water Solubility

Soluble in water.

Refractive Index

n20/D 1.403(lit.)

SMILES

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C1CCOC1

InChI

InChI=1S/C4H8O/c1-2-4-5-3-1/h1-4H2/i1D2,2D2,3D2,4D2

InChIKey

WYURNTSHIVDZCO-SVYQBANQSA-N

LogP

0.7968

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

22.8

Safety Information

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GHS Hazard Pictograms

H225

H319

H335

Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Stability

Stable. Incompatible with strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate peroxides in storage if in contact with air. Highly flammable. Store under nitrogen. Hazardous polymerisation may occur.

Sensitiveness

prone to moisture absorption

Synonyms & References

English

J-524871
T2425
T3502
Tetrahydrofuran-d8 99.5atom%D
Tetrahydrofuran-d8, >=99.5 atom % D, contains 1 % (v/v) TMS
(2H4)Tetrahydro(2H4)furan
thf-d8
WYURNTSHIVDZCO-SVYQBANQSA-N
1693-74-9
deuterated thf
2,2,3,3,4,4,5,5-octadeuteriooxolane
EINECS 216-898-4
DTXSID00937620
Tetrahydrofuran-d8, >=99.5 atom % D
MFCD00044238
Tetrahydrofuran-d8, 99.95 atom % D
Tetrahydrofuran-D8
T71908
Tetrahydrofuran-d8, >=99.5 atom % D, contains 0.03 % (v/v) TMS
Octadeuterotetrahydrofuran
Tetrahydrofuran-d8 (THF-d8)
J-010530
Q1101317
FURAN-2,3,4,5-D4,TETRAHYDRO-D4-
AKOS015904238
Furan-2,3,4,5-d4, tetrahydro-d4-
Deuterated tetrahydrofuran
Tetrahydrofuran D8 >99.5%
oxolane-d8
Tetrahydrofuran D8
Furan-D4-, tetrahydro-D4-

MDL Number

MFCD00044238

FAQ

What regulatory guidelines apply to (~2~H_8_)Tetrahydrofuran (CAS: 1693-74-9)?

Tetrahydrofuran (CAS: 1693-74-9) is classified as a flammable liquid under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). It is subject to regulations such as REACH in the European Union, which requires registration for substances above 1 tonne per year. In the United States, the EPA and FDA have specific requirements for the handling and disposal of this compound due to its flammability and potential for skin irritation.

Are there alternatives to (~2~H_8_)Tetrahydrofuran (CAS: 1693-74-9) in synthesis?

There are several alternatives to (~2~H_8_)Tetrahydrofuran (CAS: 1693-74-9) in synthesis, including 1,4-dioxane and 1,3-dioxolane. These compounds offer similar ring structures and can be used in various reactions such as ring-opening polymerizations and as solvents. However, it's important to consider the specific application and any regulatory or environmental concerns associated with each alternative.

What is the market or research trend for (~2~H_8_)Tetrahydrofuran (CAS: 1693-74-9)?

The market for (~2~H_8_)Tetrahydrofuran (CAS: 1693-74-9) is driven by its use as a solvent in the production of pharmaceuticals, polymers, and coatings. Recent research trends focus on its use in green chemistry processes and as a more sustainable alternative to some traditional solvents. However, there is ongoing interest in developing safer and more environmentally friendly compounds to replace (~2~H_8_)Tetrahydrofuran due to its flammability and potential health risks.

How should waste containing (~2~H_8_)Tetrahydrofuran (CAS: 1693-74-9) be handled?

Waste containing (~2~H_8_)Tetrahydrofuran (CAS: 1693-74-9) should be collected in appropriate containers and stored in a well-ventilated area away from ignition sources. Incineration is a common method for disposal, but professional waste disposal services should be used to ensure compliance with local regulations. Environmental protection precautions include ensuring that waste does not enter waterways and that proper personal protective equipment is used during handling and disposal operations.