Apremilast Impurity 66

Basic Information

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CAS Number

16533-45-2

Molecular Formula

C10H9NO6

Molecular Weight

239.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

157 ºC

SMILES

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CCOC(=O)C1=C(C(=CC=C1)[N+](=O)[O-])C(=O)O

InChI

InChI=1S/C10H9NO6/c1-2-17-10(14)6-4-3-5-7(11(15)16)8(6)9(12)13/h3-5H,2H2,1H3,(H,12,13)

InChIKey

SZAOZGFHEAVFMM-UHFFFAOYSA-N

LogP

1.99290

Complexity

323

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MFCD01365751
SY103119
AKOS016011682
2-(ethoxycarbonyl) -6-nitrobenzoic acid
Ethyl 2-carboxy-3-nitrobenzoate
SCHEMBL1096955
2-CARBOXY-3-ETHYLNITROBENZOATE
CS-W006239
Z1741982278
EN300-7403112
SZAOZGFHEAVFMM-UHFFFAOYSA-N
2-(ETHOXYCARBONYL)-6-NITROBENZOIC ACID
2-(ETHOXYCARBONYL)-6-NITROBENZOICACID
DS-2869
A882398
2-ethoxycarbonyl-6-nitrobenzoic acid
16533-45-2
1,2-Benzenedicarboxylic acid, 3-nitro-, 1-ethyl ester
2-(Ethoxycarbonyl)-6-nitrobenzoic acid
1,2-Benzenedicarboxylicacid, 3-nitro-, 1-ethyl ester
2-CARBOXY-3-ETHYL NITROBENZOATE
1-Ethyl-3-nitrophthalate
2-(Ethoxycarbonyl)-6-nitrobenzoic Acid 2-
2-Carboxy-3-nitrobenzoic acid ethyl ester
3-Nitrophthalic acid 2-ethyl ester
3-Nitro-phthalic acid 1-ethyl ester
ST2416207
AX8072450
AB0050965
Z4260

MDL Number

MFCD01365751

Customs Code

2918990090

FAQ

What regulatory guidelines apply to Apremilast Impurity 66 (CAS: 16533-45-2)?

Apremilast Impurity 66 (CAS: 16533-45-2) is subject to various regulatory guidelines including the REACH regulations in the European Union, which require registration of substances above a certain tonnage. Additionally, it must comply with GHS (Globally Harmonized System of Classification and Labeling of Chemicals) for hazard classification and labeling. In the USA, it is regulated by the EPA and FDA for safety and environmental protection.

Are there alternatives to Apremilast Impurity 66 (CAS: 16533-45-2) in synthesis?

In the synthesis of drugs containing Apremilast Impurity 66 (CAS: 16533-45-2), chemists often explore alternative reagents such as other impurities or isomers that can serve as viable substitutes. These alternatives can offer similar reactivity but with different impurity profiles, providing flexibility in synthetic routes.

What is the market or research trend for Apremilast Impurity 66 (CAS: 16533-45-2)?

The market and research trends for Apremilast Impurity 66 (CAS: 16533-45-2) are closely linked to the overall demand for apremilast, the primary drug it is associated with. Ongoing research focuses on optimizing the production process to reduce impurities and improve product quality. Additionally, there is an increasing emphasis on developing more sustainable and environmentally friendly synthetic methods.

How should waste containing Apremilast Impurity 66 (CAS: 16533-45-2) be handled?

Waste containing Apremilast Impurity 66 (CAS: 16533-45-2) should be collected in appropriate containers and stored according to local regulations. For disposal, incineration is a common method, but professional waste disposal services are recommended to ensure compliance with environmental protection standards. Proper documentation and labeling of the waste are essential to avoid contamination and ensure safe handling.