Azacitidine Impurity 11

Basic Information

View in Editor

CAS Number

16352-06-0

Molecular Formula

C4H6N4O

Molecular Weight

126.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

>350 ºC

Boiling Point

233.3±23.0 ºC (760 Torr),

Flash Point

94.9±22.6 ºC,

SMILES

View in Editor

CC1=NC(=NC(=O)N1)N

InChI

InChI=1S/C4H6N4O/c1-2-6-3(5)8-4(9)7-2/h1H3,(H3,5,6,7,8,9)

InChIKey

UUTHDVPZNWJUFV-UHFFFAOYSA-N

LogP

-0.9444800000000002

Topological Polar Surface Area

84.66 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

205

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4-Amino-6-methyl-1,3,5-triazin-2-ol
AKOS026731019
AKOS006223437
DTXSID80274686
A810482
AKOS015999717
SB73412
AM20120521
1,3,5-Triazin-2(1H)-one, 6-amino-4-methyl-
FT-0611112
2-AMINO-4-HYDROXY-6-
Acetoguanide
TS-00005
NS00067686
2-amino-6-methyl-1H-1,3,5-triazin-4-one
MFCD00052767
BP-11347
4-amino-6-methyl-1,3,5-triazin-2-ol, AldrichCPR
2-Amino-4-hydroxy-6-methyl-1,3,5-triazine
BCP21532
1,3,5-Triazin-2(1H)-one,6-amino-4-methyl-
16352-06-0
SY104111
1,3,5-Triazin-2(1H)-one, 4-amino-6-methyl-
4-amino-6-methyl-1H-1,3,5-triazin-2-one
CS-W022076
SCHEMBL1096504
4-Amino-6-methyl-1 pound not3 pound not5-triazin-2-ol
SCHEMBL13833614
6-amino-4-methyl-1,2-dihydro-1,3,5-triazin-2-one
1,3,5-Triazin-2(1H)-one, 6-amino-4-methyl

MDL Number

MFCD25978474

Customs Code

2933699090

FAQ

What are the physical and chemical properties of Azacitidine Impurity 11 (CAS: 16352-06-0)?

Azacitidine Impurity 11 (CAS: 16352-06-0) is a crystalline compound with a molecular weight of approximately 183.17 g/mol. It is sparingly soluble in water and ethanol. This impurity exhibits low reactivity under normal conditions, making it stable under various environmental and storage conditions. It is used in pharmaceutical research and development, particularly in the synthesis of nucleoside analogs.

How is Azacitidine Impurity 11 (CAS: 16352-06-0) typically synthesized?

Azacitidine Impurity 11 (CAS: 16352-06-0) is synthesized through a multi-step organic reaction process. The synthesis typically involves the condensation of a specific carbamoyl chloride with a nucleoside derivative. The process requires the use of a Lewis acid catalyst, such as aluminum chloride, to promote the reaction. High selectivity and yield are achieved under controlled conditions in a fume hood.

What industries use Azacitidine Impurity 11 (CAS: 16352-06-0)?

Azacitidine Impurity 11 (CAS: 16352-06-0) is primarily used in the pharmaceutical industry for the development and production of anti-cancer drugs. It is also utilized in research laboratories for the study of nucleoside analogs and their applications in targeted therapies.

What precautions should be taken when handling Azacitidine Impurity 11 (CAS: 16352-06-0)?

When handling Azacitidine Impurity 11 (CAS: 16352-06-0), it is recommended to wear appropriate personal protective equipment (PPE), including gloves, laboratory coat, and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation. In case of a spill, avoid direct contact and neutralize with an appropriate chemical before cleaning up. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.