5-Chlorosaligenyl-N,N-diisopropylphosphoramidite | CAS No. 1620086-77-2

Q: What are the physical and chemical properties of 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2)?

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is a white crystalline solid with a molecular weight of approximately 432.09 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and dichloromethane. The compound exhibits a high reactivity in nucleophilic substitution reactions and is commonly used in organic synthesis due to its phosphoramidite functionality.

Q: How is 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) typically synthesized?

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is typically synthesized via a multi-step process involving the reaction of chloroacetyl chloride with saligenin, followed by the addition of diisopropyl phosphorochloridite. The reaction is catalyzed by a base such as triethylamine, and the product is isolated through recrystallization to obtain the crystalline form.

Q: What industries use 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2)?

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is primarily used in the pharmaceutical industry for the synthesis of various pharmaceutical compounds. It is also utilized in the semiconductor industry for modifying functional groups on organic materials used in the fabrication of electronic devices and in the polymer industry for introducing specific functionalities into polymers.

Q: What precautions should be taken when handling 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2)?

When handling 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbent materials, and proper disposal methods should be followed. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite

Basic Information

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CAS Number

1620086-77-2

Molecular Formula

C13H19ClNO2P

Molecular Weight

287.72 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Insecticides

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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Clc1ccc2c(c1)COP(O2)N(C(C)C)C(C)C

InChI

InChI=1S/C13H19ClNO2P/c1-9(2)15(10(3)4)18-16-8-11-7-12(14)5-6-13(11)17-18/h5-7,9-10H,8H2,1-4H3

InChIKey

ZJPWJYRCWIYHMH-UHFFFAOYSA-N

LogP

4.594700000000004

Topological Polar Surface Area

21.700000000000003 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

270

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite
i>,<i>N<
6-Chloro-N,N-diisopropyl-4H-benzo[d][1,3,2]dioxaphosphinin-2-amine
6-chloro-N,N-di(propan-2-yl)-4H-1,3,2-benzodioxaphosphinin-2-amine

MDL Number

MFCD30725743

FAQ

What are the physical and chemical properties of 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2)?

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is a white crystalline solid with a molecular weight of approximately 432.09 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and dichloromethane. The compound exhibits a high reactivity in nucleophilic substitution reactions and is commonly used in organic synthesis due to its phosphoramidite functionality.

How is 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) typically synthesized?

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is typically synthesized via a multi-step process involving the reaction of chloroacetyl chloride with saligenin, followed by the addition of diisopropyl phosphorochloridite. The reaction is catalyzed by a base such as triethylamine, and the product is isolated through recrystallization to obtain the crystalline form.

What industries use 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2)?

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is primarily used in the pharmaceutical industry for the synthesis of various pharmaceutical compounds. It is also utilized in the semiconductor industry for modifying functional groups on organic materials used in the fabrication of electronic devices and in the polymer industry for introducing specific functionalities into polymers.

What precautions should be taken when handling 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2)?

When handling 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbent materials, and proper disposal methods should be followed. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.