5-Chlorosaligenyl-N,N-diisopropylphosphoramidite(CAS: 1620086-77-2)

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is a white crystalline solid with a molecular weight of approximately 432.09 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and dichloromethane. The compound exhibits a high reactivity in nucleophilic substitution reactions and is commonly used in organic synthesis due to its phosphoramidite functionality.

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is typically synthesized via a multi-step process involving the reaction of chloroacetyl chloride with saligenin, followed by the addition of diisopropyl phosphorochloridite. The reaction is catalyzed by a base such as triethylamine, and the product is isolated through recrystallization to obtain the crystalline form.

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2) is primarily used in the pharmaceutical industry for the synthesis of various pharmaceutical compounds. It is also utilized in the semiconductor industry for modifying functional groups on organic materials used in the fabrication of electronic devices and in the polymer industry for introducing specific functionalities into polymers.

When handling 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (CAS: 1620086-77-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbent materials, and proper disposal methods should be followed. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.