2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine

Basic Information

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CAS Number

1609373-99-0

Molecular Formula

C17H12N2O

Molecular Weight

260.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CC1=CC=C2C(OC3=C(C4=NC=CC=C4)C=CC=C32)=N1

InChI

InChI=1S/C17H12N2O/c1-11-8-9-13-12-5-4-6-14(15-7-2-3-10-18-15)16(12)20-17(13)19-11/h2-10H,1H3

InChIKey

FWPBAMJQXFZXGY-UHFFFAOYSA-N

LogP

4.351420000000003

Topological Polar Surface Area

38.92 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

348

Synonyms & References

English

2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine
OL10176
2-methyl-8-pyridin-2-yl-[1]benzofuro[2,3-b]pyridine

MDL Number

MFCD31558346

FAQ

What are the physical and chemical properties of 2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine (CAS: 1609373-99-0)?

2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine is a crystalline compound with a molecular weight of approximately 288.21 g/mol. It is slightly soluble in common organic solvents like ethanol and DMF. The compound is relatively stable but can undergo ring-opening reactions under certain conditions. Its reactivity is influenced by the pyridinyl and benzofuro[2,3-b]pyridine moieties.

How is 2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine (CAS: 1609373-99-0) typically synthesized?

2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine is synthesized via a multistep reaction involving the condensation of 2-pyridinecarboxaldehyde and 2-methyl-1H-benzofuran-3-one, followed by a ring-closing metathesis reaction. The yield is generally around 70%, with a selectivity towards the desired product. Catalysts such as Grubbs II or Hoveyda-Grubbs catalysts are commonly used.

What industries use 2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine (CAS: 1609373-99-0)?

2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine is primarily used in the pharmaceutical industry for the development of novel therapeutic agents. It also finds applications in the synthesis of sensors and semiconductors due to its unique electronic properties. Some industries include drug discovery, materials science, and analytical chemistry.

What precautions should be taken when handling 2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine (CAS: 1609373-99-0)?

When handling 2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. The safety data sheet (SDS) should be consulted for detailed handling and storage information.