2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine(CAS: 1609373-99-0)

2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine is a crystalline compound with a molecular weight of approximately 288.21 g/mol. It is slightly soluble in common organic solvents like ethanol and DMF. The compound is relatively stable but can undergo ring-opening reactions under certain conditions. Its reactivity is influenced by the pyridinyl and benzofuro[2,3-b]pyridine moieties.

2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine is synthesized via a multistep reaction involving the condensation of 2-pyridinecarboxaldehyde and 2-methyl-1H-benzofuran-3-one, followed by a ring-closing metathesis reaction. The yield is generally around 70%, with a selectivity towards the desired product. Catalysts such as Grubbs II or Hoveyda-Grubbs catalysts are commonly used.

2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine is primarily used in the pharmaceutical industry for the development of novel therapeutic agents. It also finds applications in the synthesis of sensors and semiconductors due to its unique electronic properties. Some industries include drug discovery, materials science, and analytical chemistry.

When handling 2-Methyl-8-(2-pyridinyl)[1]benzofuro[2,3-b]pyridine, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. The safety data sheet (SDS) should be consulted for detailed handling and storage information.