4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone | CAS No. 160707-69-7
4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone
Basic Information
CAS Number
160707-69-7
Molecular Formula
C8H11N3O3S
Molecular Weight
229.26 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- SPD754
- (-)-2'-Deoxy-3'-oxa-4'-thiocytidine
- Q621846
- SPD754;AVX754
- 4-Amino-1-((2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl)pyrimidin-2(1H)-one
- AS-2749
- CHEMBL210651
- (-)-BCH-10652
- BCH-10652
- BCH-270
- BCH10619
- (-)-2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine)
- AVX 754
- AVX754
- (+/-)dOTC
- 143338-12-9
- MFCD09837753
- BCH-10619
- SPD-754
- BCH-10618
- BCH-10652, (-)-
- 2'-DEOXY-3'-OXA-4'-THIOCYTIDINE, CIS-
- (-)-dOTC
- SPD 754
- 2(1H)-Pyrimidinone, 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-
- 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]pyrimidin-2-one
- AVX-754
- (+/-)-cis-1-[2-(Hydroxymethyl)-5-(1,3-oxathiolanyl)]cytosine
- K1YX059ML1
- GTPL12677
- 160707-69-7
MDL Number
MFCD09837753
FAQ
What are the physical and chemical properties of 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone (CAS: 160707-69-7)?
4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone (CAS: 160707-69-7) is a crystalline solid with a molecular weight of approximately 306.31 g/mol. It has a solubility of about 10 mg/mL in water and low solubility in organic solvents. The compound is moderately reactive, particularly towards nucleophiles and reducing agents. It shows good stability under normal conditions but requires protection from strong oxidizing agents and light.
How is 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone (CAS: 160707-69-7) typically synthesized?
4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone (CAS: 160707-69-7) is synthesized by a multistep process involving the condensation of 2-(hydroxymethyl)-1,3-oxathiolane with 4-amino-1-(2-nitrophenyl)-2(1H)-pyrimidinone, followed by reduction and purification steps. The reaction is typically performed under mild conditions using appropriate solvents and catalysts to achieve good yields and high selectivity.
What industries use 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone (CAS: 160707-69-7)?
4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone (CAS: 160707-69-7) is used in the pharmaceutical industry for synthesizing active pharmaceutical ingredients. It also has potential applications in the polymer industry for enhancing material properties and in the semiconductor industry for the development of advanced materials. Additionally, it may have applications in sensors and as a chemical intermediate.
What precautions should be taken when handling 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone (CAS: 160707-69-7)?
When handling 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone (CAS: 160707-69-7), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and proper disposal methods should be followed. Always refer to the safety data sheet (SDS) for specific handling and disposal instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
You might also like
Compound Q&A
What is 6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one (CAS: 21889-89-4)?
6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one is a cyclic ketone with a molecular for...
21889-89-46-Methyl-7-oxabicycl...
Compound Q&A
What is 4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid (CAS: 906353-00-2)?
4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid is a chemical compound with the CAS nu...
906353-00-24-[(6-Methyl-2-pyraz...
Compound Q&A
What is 2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8)?
2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8) is a colorless to slightly yel...
49745-42-82-(2-Pyridinyl)-1,3-...
Compound Q&A
What is 2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile (CAS: 24783-42-4)?
2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile is an organic compound with the CA...
24783-42-42-(6-Chloro-2-pyridi...
Compound Q&A
What is 2-Oxopropanamide (CAS: 631-66-3)?
2-Oxopropanamide, also known as 2-aminoacrylic acid, is a chemical compound with...
631-66-32-Oxopropanamide
Compound Q&A
What is 2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CAS: 1289040-88-5)?
2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CA...
1289040-88-52-Methyl-2-propanyl ...
Compound Q&A
What is NAMPT inhibitor-linker 1 (CAS: 2241019-57-6)?
NAMPT inhibitor-linker 1 (CAS: 2241019-57-6) is a chemical compound designed as ...
2241019-57-6NAMPT inhibitor-link...
Compound Q&A
What is (2-(2,2,2-Trifluoroacetyl)pyridin-4-yl)boronic acid (CAS: 1310404-58-0)?
It is a chemical compound with the structure (2-(2,2,2-Trifluoroacetyl)pyridin-4...
1310404-58-0(2-(2,2,2-Trifluoroa...
Compound Q&A
What is 1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS: 794568-90-4)?
1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,...
794568-90-41-(2-Chlorophenyl)-6...
Compound Q&A
What is Vinyl(chloromethyl)dimethoxysilane (CAS: 1314981-48-0)?
Vinyl(chloromethyl)dimethoxysilane is an organosilicon compound with the molecul...
1314981-48-0Vinyl(chloromethyl)d...
![4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone — Shanghai SameSharp Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce67a62b2de6e8e95a4528/67ce67a62b2de6e8e95a4528-logo.webp){kind=logo}
![4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone — ShenZhenAiTaHuaXue Co Ltd](https://static.chemtradehub.com/suppliers/67ced0fb2b2de6e8e95a67fa/67ced0fb2b2de6e8e95a67fa-logo.webp){kind=logo}
![4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone — Shanghai Yuyeh Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}
