4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline | CAS No. 1602859-53-9

4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline

Basic Information

CAS Number

1602859-53-9

Molecular Formula

C10H6ClFINO

Molecular Weight

337.52 g/mol

AD

Basic Physical Properties

Boiling Point

387.5±37.0℃/760mmHg

COc1cc2c(Cl)c(I)cnc2cc1F

InChI

InChI=1S/C10H6ClFINO/c1-15-9-2-5-8(3-6(9)12)14-4-7(13)10(5)11/h2-4H,1H3

InChIKey

JOLRWGDFPFFFJG-UHFFFAOYSA-N

LogP

3.640500000000001

Topological Polar Surface Area

22.12 Ų

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

234

Synonyms & References

English

  • 4-Chloro-7-fluoro-3-iodo-6-methoxy-quinoline
  • Quinoline, 4-chloro-7-fluoro-3-iodo-6-methoxy-
  • 4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline
  • BCP18360
  • AK535344

MDL Number

MFCD28139442

FAQ

What are the physical and chemical properties of 4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline (CAS: 1602859-53-9)?

4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline is a solid with a crystalline form. The molecular weight is approximately 405.09 g/mol. It is slightly soluble in water and highly soluble in organic solvents like methanol and DMF. The compound is known for its reactivity, particularly in nucleophilic substitution reactions.

How is 4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline (CAS: 1602859-53-9) typically synthesized?

4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline is typically synthesized through a multistep process involving the introduction of chlorine, iodine, and methoxy groups onto the quinoline ring. Common reagents include iodine and methanol, with the use of Lewis acids as catalysts. The yield and selectivity of the reaction can range depending on the specific conditions.

What industries use 4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline (CAS: 1602859-53-9)?

4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline is primarily used in the pharmaceutical industry, where it serves as a precursor for drug synthesis. It is also used in the development of polymer-based materials and as a component in electronic sensors due to its unique chemical properties.

What precautions should be taken when handling 4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline (CAS: 1602859-53-9)?

When handling 4-Chloro-7-fluoro-3-iodo-6-methoxyquinoline, it is crucial to use appropriate Personal Protective Equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be used in a fume hood due to its volatility and potential health hazards. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be well-ventilated. It is also advisable to refer to the Safety Data Sheet (SDS) for detailed safety information.

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