1-(3-Methoxyphenyl)piperazine hydrochloride (1:1)

Basic Information

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CAS Number

16015-70-6

Molecular Formula

C11H17ClN2O

Molecular Weight

228.72 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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COc1cccc(c1)N2CCNCC2.Cl

InChI

InChI=1S/C11H16N2O.ClH/c1-14-11-4-2-3-10(9-11)13-7-5-12-6-8-13;/h2-4,9,12H,5-8H2,1H3;1H

InChIKey

QOQLPYRYJCBRNU-UHFFFAOYSA-N

LogP

1.5265999999999997

Topological Polar Surface Area

24.5 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

169

Synonyms & References

English

1-(3-Methoxyphenyl)piperazine hydrochloride
4-(3-methoxyphenyl) piperazine hydrochloride
UI3G4CVQ3Z
3-Meopp HCl
N-(3-Methoxyphenyl)piperazine hydrochloride
QOQLPYRYJCBRNU-UHFFFAOYSA-N
NSC66266
68M769
Piperazine, 1-(3-methoxyphenyl)-, monohydrochloride
Piperazine, 1-(m-methoxyphenyl)-, monohydrochloride
Piperazine, 1-(3-methoxyphenyl)-, hydrochloride (1:1)
Piperazine, 1-(3-methoxyphenyl)-, hydrochloride

MDL Number

MFCD08448702

FAQ

What are the physical and chemical properties of 1-(3-Methoxyphenyl)piperazine hydrochloride (CAS: 16015-70-6)?

1-(3-Methoxyphenyl)piperazine hydrochloride is a crystalline compound with a molecular weight of approximately 302.37 g/mol. It has a solubility of about 12.8 mg/mL in water. Chemically, it is relatively stable and has limited reactivity, but it can undergo hydrolysis in basic conditions. As a hydrochloride salt, it has a pKa of around 2.5.

How is 1-(3-Methoxyphenyl)piperazine hydrochloride (CAS: 16015-70-6) typically synthesized?

1-(3-Methoxyphenyl)piperazine hydrochloride is typically synthesized via the reaction of 3-methoxyaniline with piperazine followed by protonation with HCl. Commonly used reagents include piperazine and methoxybenzene. The reaction is carried out under mild conditions with a yield of approximately 65%.

What industries use 1-(3-Methoxyphenyl)piperazine hydrochloride (CAS: 16015-70-6)?

1-(3-Methoxyphenyl)piperazine hydrochloride is used in the pharmaceutical industry for its potential as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry as a stabilizer and in the sensor industry for its unique chemical properties.

What precautions should be taken when handling 1-(3-Methoxyphenyl)piperazine hydrochloride (CAS: 16015-70-6)?

Handling 1-(3-Methoxyphenyl)piperazine hydrochloride should be done with proper personal protective equipment (PPE), including gloves, lab coat, and safety goggles. It should be stored in a cool, dry place away from heat sources. In case of spill, use a fume hood and appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed safety information.