1-(3-Methoxyphenyl)piperazine hydrochloride (1:1)(CAS: 16015-70-6)

1-(3-Methoxyphenyl)piperazine hydrochloride is a crystalline compound with a molecular weight of approximately 302.37 g/mol. It has a solubility of about 12.8 mg/mL in water. Chemically, it is relatively stable and has limited reactivity, but it can undergo hydrolysis in basic conditions. As a hydrochloride salt, it has a pKa of around 2.5.

1-(3-Methoxyphenyl)piperazine hydrochloride is typically synthesized via the reaction of 3-methoxyaniline with piperazine followed by protonation with HCl. Commonly used reagents include piperazine and methoxybenzene. The reaction is carried out under mild conditions with a yield of approximately 65%.

1-(3-Methoxyphenyl)piperazine hydrochloride is used in the pharmaceutical industry for its potential as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry as a stabilizer and in the sensor industry for its unique chemical properties.

Handling 1-(3-Methoxyphenyl)piperazine hydrochloride should be done with proper personal protective equipment (PPE), including gloves, lab coat, and safety goggles. It should be stored in a cool, dry place away from heat sources. In case of spill, use a fume hood and appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed safety information.