5-Fluoro-2-iodopyridine

Basic Information

View in Editor

CAS Number

159870-80-1

Molecular Formula

C5H3FIN

Molecular Weight

222.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

197 ºC

Flash Point

73 ºC

SMILES

View in Editor

C1=CC(=NC=C1F)I

InChI

InChI=1S/C5H3FIN/c6-4-1-2-5(7)8-3-4/h1-3H

InChIKey

SKKQNFJMWPLVDB-UHFFFAOYSA-N

LogP

1.8253

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

78.8

Synonyms & References

English

5-fluoranyl-2-iodanyl-pyridine
SY041123
159870-80-1
DS-11208
Pyridine,5-fluoro-2-iodo-
DTXSID40628606
J-517509
CS-W022378
5-fluoro-2-iodopyridine
SKKQNFJMWPLVDB-UHFFFAOYSA-N
AB42989
EN300-4266687
2-Iodo-5-Fluoropyridine
AC-26389
AKOS015853322
PYRIDINE, 5-FLUORO-2-IODO-
A810078
SCHEMBL1118715
FT-0645432
MFCD07787574
5-Fluoro-2-iodopyridine
Pyridine,5-fluoro-2-iodo
WT2045
VP13808
RP27428
AB0021011
V2142
ST2403301

MDL Number

MFCD07787574

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Fluoro-2-iodopyridine (CAS: 159870-80-1)?

5-Fluoro-2-iodopyridine is a crystalline solid at room temperature. It has a molecular weight of approximately 257.02 g/mol. This compound is poorly soluble in water but soluble in organic solvents like acetonitrile. It is highly reactive due to the presence of the iodine and fluorine substituents, which can participate in various chemical reactions such as nucleophilic substitution and electrophilic aromatic substitution.

How is 5-Fluoro-2-iodopyridine (CAS: 159870-80-1) typically synthesized?

5-Fluoro-2-iodopyridine is typically synthesized through a multistep process involving the iodination of 2-fluoropyridine followed by a nucleophilic substitution reaction. The synthesis often requires the use of iodine and a base like potassium carbonate as a catalyst. The reaction is carried out in an aprotic solvent like acetonitrile, yielding the target compound with good selectivity and moderate to high yield.

What industries use 5-Fluoro-2-iodopyridine (CAS: 159870-80-1)?

5-Fluoro-2-iodopyridine is used in various industries, including pharmaceuticals for the synthesis of drug intermediates, polymers for the development of new materials, and sensors for detecting specific chemical compounds. It also has potential applications in semiconductors due to its electronic properties.

What precautions should be taken when handling 5-Fluoro-2-iodopyridine (CAS: 159870-80-1)?

Proper handling of 5-Fluoro-2-iodopyridine requires the use of personal protective equipment (PPE) such as gloves, goggles, and lab coats. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be handled with appropriate absorbent materials and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed handling and emergency procedures.