Compound Q&A

How is 5-Fluoro-2-iodopyridine (CAS: 159870-80-1) typically synthesized?

Answer

5-Fluoro-2-iodopyridine
5-Fluoro-2-iodopyridine is typically synthesized through a multistep process involving the iodination of 2-fluoropyridine followed by a nucleophilic substitution reaction. The synthesis often requires the use of iodine and a base like potassium carbonate as a catalyst. The reaction is carried out in an aprotic solvent like acetonitrile, yielding the target compound with good selectivity and moderate to high yield.

About

English Name 5-Fluoro-2-iodopyridine
Molecular Formula C5H3FIN
Molecular Weight 222.99 g/mol
SMILES C1=CC(=NC=C1F)I
InChIKey SKKQNFJMWPLVDB-UHFFFAOYSA-N
Last Updated: 2025-10-22 19:24

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