2-(4-Chlorophenyl)ethylamine

Basic Information

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CAS Number

156-41-2

Molecular Formula

C8H10ClN

Molecular Weight

155.63 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

140°C/25mmHg

Refractive Index

n20/D 1.548(lit.)

SMILES

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C1=CC(=CC=C1CCN)Cl

InChI

InChI=1S/C8H10ClN/c9-8-3-1-7(2-4-8)5-6-10/h1-4H,5-6,10H2

InChIKey

SRXFXCKTIGELTI-UHFFFAOYSA-N

LogP

1.8412

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

87.3

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

EN300-17862
4-Chlorobenzeneethanamine
AC-13735
para-chlorophenethylamine
AS-19149
SCHEMBL232327
2-(4-Chlorophenyl)ethanamine
2-(4-chlorophenyl)ethan-1-amine
SCHEMBL8936661
1-Amino-2-(4-chlorophenyl)ethane
AMY15451
2-(4-Chlorophenyl)ethylamine, 98%
Benzeneethanamine, 4-chloro-, hydrochloride (1:1)
2-(4chlorophenyl)ethylamine
NS00025079
F2190-0501
156-41-2
SY006689
Benzeneethanamine, 4-chloro-
2-(4-chlorophenyl) ethylamine
.beta.-(p-Chlorophenyl)ethylamine
HMS1719C19
FT-0608627
2-(4'-Chlorophenyl)ethylamine
AKOS000120500
4-chlorophenylethylamine
2-(4 chlorophenyl)ethylamine
J-650304
2-(4-chloro-phenyl)-ethylamine
2-(p-Chlorophenyl)ethylamine 4-Chlorophenethylamine
SB33918

MDL Number

MFCD00008191

Customs Code

2921499090

FAQ

What are the physical and chemical properties of 2-(4-Chlorophenyl)ethylamine (CAS: 156-41-2)?

2-(4-Chlorophenyl)ethylamine is a white, crystalline solid with a molecular weight of approximately 190.63 g/mol. It has a pKa of about 10.3 and is slightly soluble in water. This compound is known to be reactive towards nucleophiles and is prone to substitution reactions due to the presence of the chlorophenyl group and the secondary amine. It is also susceptible to hydrolysis under basic conditions.

How is 2-(4-Chlorophenyl)ethylamine (CAS: 156-41-2) typically synthesized?

2-(4-Chlorophenyl)ethylamine is typically synthesized by reacting 4-chlorobenzyl halide with an amine, often in the presence of a base like sodium hydride or potassium tert-butoxide. The reaction is conducted in a solvent such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO) to ensure good solubility and to facilitate the nucleophilic reaction. The yield and selectivity can vary depending on the specific conditions used.

What industries use 2-(4-Chlorophenyl)ethylamine (CAS: 156-41-2)?

2-(4-Chlorophenyl)ethylamine is used in various industries, including pharmaceuticals for the synthesis of certain drugs, as a precursor in polymer synthesis, in the development of sensors for detecting specific chemicals, and in the production of materials for semiconductors. Its chemical properties make it suitable for applications requiring a specific functional group for further derivatization.

What precautions should be taken when handling 2-(4-Chlorophenyl)ethylamine (CAS: 156-41-2)?

When handling 2-(4-Chlorophenyl)ethylamine (CAS: 156-41-2), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or fume hood due to its potential to release toxic fumes. Spills should be cleaned up carefully, following standard procedures for hazardous materials. Always refer to the safety data sheet (SDS) for specific handling guidelines and emergency procedures.