2-(4-Chlorophenyl)ethylamine(CAS: 156-41-2)

2-(4-Chlorophenyl)ethylamine is a white, crystalline solid with a molecular weight of approximately 190.63 g/mol. It has a pKa of about 10.3 and is slightly soluble in water. This compound is known to be reactive towards nucleophiles and is prone to substitution reactions due to the presence of the chlorophenyl group and the secondary amine. It is also susceptible to hydrolysis under basic conditions.

2-(4-Chlorophenyl)ethylamine is typically synthesized by reacting 4-chlorobenzyl halide with an amine, often in the presence of a base like sodium hydride or potassium tert-butoxide. The reaction is conducted in a solvent such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO) to ensure good solubility and to facilitate the nucleophilic reaction. The yield and selectivity can vary depending on the specific conditions used.

2-(4-Chlorophenyl)ethylamine is used in various industries, including pharmaceuticals for the synthesis of certain drugs, as a precursor in polymer synthesis, in the development of sensors for detecting specific chemicals, and in the production of materials for semiconductors. Its chemical properties make it suitable for applications requiring a specific functional group for further derivatization.

When handling 2-(4-Chlorophenyl)ethylamine (CAS: 156-41-2), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or fume hood due to its potential to release toxic fumes. Spills should be cleaned up carefully, following standard procedures for hazardous materials. Always refer to the safety data sheet (SDS) for specific handling guidelines and emergency procedures.