Cathelicidin | CAS No. 154947-66-7

Cathelicidin

Basic Information

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CAS Number

154947-66-7

Molecular Formula

C205H340N60O53

Molecular Weight

4493 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)CC)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(C)C)N

InChI

InChI=1S/C205H340N60O53/c1-20-114(16)162(261-179(296)128(66-40-46-86-211)235-176(293)135(74-78-155(273)274)243-170(287)125(63-37-43-83-208)241-192(309)148(106-266)257-174(291)126(64-38-44-84-209)234-171(288)129(67-47-87-225-201(215)216)240-185(302)142(98-119-55-29-24-30-56-119)252-187(304)144(100-121-59-33-26-34-60-121)253-189(306)146(102-158(279)280)233-154(272)104-230-167(284)138(94-109(6)7)248-166(283)122(212)93-108(4)5)194(311)231-105-153(271)232-123(61-35-41-81-206)168(285)242-136(75-79-156(275)276)177(294)251-141(97-118-53-27-23-28-54-118)184(301)238-124(62-36-42-82-207)169(286)236-131(69-49-89-227-203(219)220)181(298)263-164(116(18)22-3)197(314)259-160(112(12)13)195(312)246-134(73-77-151(213)269)175(292)237-132(70-50-90-228-204(221)222)180(297)262-163(115(17)21-2)196(313)245-127(65-39-45-85-210)172(289)256-147(103-159(281)282)190(307)254-143(99-120-57-31-25-32-58-120)186(303)249-139(95-110(8)9)183(300)239-130(68-48-88-226-202(217)218)173(290)255-145(101-152(214)270)188(305)250-140(96-111(10)11)191(308)260-161(113(14)15)199(316)265-92-52-72-150(265)193(310)244-133(71-51-91-229-205(223)224)182(299)264-165(117(19)268)198(315)247-137(76-80-157(277)278)178(295)258-149(107-267)200(317)318/h23-34,53-60,108-117,122-150,160-165,266-268H,20-22,35-52,61-107,206-212H2,1-19H3,(H2,213,269)(H2,214,270)(H,230,284)(H,231,311)(H,232,271)(H,233,272)(H,234,288)(H,235,293)(H,236,286)(H,237,292)(H,238,301)(H,239,300)(H,240,302)(H,241,309)(H,242,285)(H,243,287)(H,244,310)(H,245,313)(H,246,312)(H,247,315)(H,248,283)(H,249,303)(H,250,305)(H,251,294)(H,252,304)(H,253,306)(H,254,307)(H,255,290)(H,256,289)(H,257,291)(H,258,295)(H,259,314)(H,260,308)(H,261,296)(H,262,297)(H,263,298)(H,264,299)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,317,318)(H4,215,216,225)(H4,217,218,226)(H4,219,220,227)(H4,221,222,228)(H4,223,224,229)/t114-,115-,116-,117+,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,160-,161-,162-,163-,164-,165-/m0/s1

InChIKey

POIUWJQBRNEFGX-XAMSXPGMSA-N

LogP

-14.633950000000368

Topological Polar Surface Area

1901.1199999999983 Å²

Hydrogen Bond Donor/Acceptor

82 / 113

Complexity

10700

Synonyms & References

English

hCAP 18
Cathelicidin antimicrobial peptide 18
LL-37/hCAP18
Cap-18
LL-37
CHEMBL530345
ropocamptide
LL-37 (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-acid)
LL-37(human)
CAP18,
NH2-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-COOH
LL 37
EX-A7429A
All38 peptide
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
AKOS024458536
RS-2000
Bac4
Cathelicidin
Cathelicidin LL 37
154947-66-7
LL-37 (Human)
Cathelicidin LL 37 (human)
Cathelicidin LL-37
Peptide LL 37 (human gene FALL39 antibacterial)
Protein CAP 18 (rabbit cationic antimicrobial 37-amino acid fragment)
LL-37 (trifluoroacetate salt)
Antibacterial Protein LL-37 (human)
Antibacterial Protein LL-37 (huMan), LL37, CAMP
H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH

MDL Number

MFCD09264694

FAQ

What are the physical and chemical properties of Cathelicidin (CAS: 154947-66-7)?

Cathelicidin (CAS: 154947-66-7) is a small antimicrobial peptide with a molecular weight of approximately 1.5 kDa. It is highly soluble in water and has good stability. Cathelicidin is reactive towards bacterial cell membranes due to its cationic nature and amphipathic structure. It exists in a crystalline form suitable for storage and transport.

How is Cathelicidin (CAS: 154947-66-7) typically synthesized?

Cathelicidin (CAS: 154947-66-7) can be synthesized through solid-phase peptide synthesis using Fmoc chemistry. Commonly, the peptide is synthesized on a resin, with Fmoc protecting groups removed stepwise. The sequence is then deprotected and the peptide is cleaved from the solid support using trifluoroacetic acid (TFA). This method provides good selectivity and yields are typically around 70-80%.

What industries use Cathelicidin (CAS: 154947-66-7)?

Cathelicidin (CAS: 154947-66-7) has applications primarily in the pharmaceutical industry, where it is used for developing antimicrobial therapies. It is also utilized in research for studying host defense peptides and has potential uses in sensor technology for detecting pathogens.

What precautions should be taken when handling Cathelicidin (CAS: 154947-66-7)?

When handling Cathelicidin (CAS: 154947-66-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Handle in a fume hood to avoid inhalation. Spills should be managed carefully using absorbent materials and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling instructions.