Adrenomedullin (AM) (13-52), human

Basic Information

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CAS Number

154765-05-6

Molecular Formula

C31H39FN6O2

Molecular Weight

546.68 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Solid

SMILES

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FC1=CC=CC(=C1CN1CC(CCC1C1CC1)NC(C1CCC2C(C(C3C=CC4=NC=CN4C=3)NN2)C1)=O)OC

InChI

1S/C31H39FN6O2/c1-40-28-4-2-3-25(32)24(28)18-38-17-22(9-11-27(38)19-5-6-19)34-31(39)20-7-10-26-23(15-20)30(36-35-26)21-8-12-29-33-13-14-37(29)16-21/h2-4,8,12-14,16,19-20,22-23,26-27,30,35-36H,5-7,9-11,15,17-18H2,1H3,(H,34,39)

InChIKey

XJOVNCGUQXEANC-UHFFFAOYSA-N

LogP

3.975200000000002

Topological Polar Surface Area

82.93 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

892

Synonyms & References

English

SER-PHE-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2: SFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2DISULFIDE BRIDGE CYS16-CYS21
ADRENOMEDULLIN (13-52) (HUMAN)
Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 (Disulfide bridge Cys16-Cys21)
SFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2 (DISULFIDE BRIDGE: 4-9)
SER-PHE-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2
H-SER-PHE-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2
H-SER-PHE-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2 (DISULFIDE BRIDGE: 4-9)
Adrenomedullin (13-52) (human) H-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 (Disulfide bond)
L-Tyrosinamide,L-seryl-L-phenylalanylglycyl-L-cysteinyl-L-arginyl-L-phenylalanylglycyl-L-threo...
L-Tyrosinamide,L-seryl-L-phenylalanylglycyl-L-cysteinyl-L-arginyl-L-phenylalanylglycyl-L-threonyl-L-cysteinyl-L-threonyl-L-va
L-Tyrosinamide,L-seryl-L-phenylalanylglycyl-L-cysteinyl-L-arginyl-L-phenylalanylglycyl-L-threonyl-L-cysteinyl-L-threonyl-L-valyl-L-glutaminyl-L-lysyl-L-leucyl-L-alanyl-L-histidyl-L-glutaminyl-L-isoleu
H-SER-PHE-GLY-CYS-ARG-PHE-GLY-THR-CYS-
L-Tyrosinamide,L-seryl-L-phenylalanylglycyl-L-cysteinyl-L-arginyl-L-phenylalanylglycyl-L-threonyl-L-cysteinyl-L-threonyl-L-valyl-L-glutaminyl-L-lysyl-L-leucyl-L-alanyl-L-histidyl-L-glutaminyl-L-isoleucyl-L-tyrosyl-L-glutaminyl-L-phenylalanyl-L-threonyl-L-a-aspartyl-L-lysyl-L-a-aspartyl-L-lysyl-L-a-aspartyl-L-asparaginyl-L-valyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-lysyl-L-isoleucyl-L-seryl-L-prolyl-L-glutaminylglycyl-,cyclic (4®9)-
BDBM154765
US8999957, Table 3, Compound 37
CID 91970795
Adrenomedullin (AM) (13-52), human
N-[6-cyclopropyl-1-[(2-fluoro-6-methoxyphenyl)methyl]piperidin-3-yl]-3-imidazo[1,2-a]pyridin-6-yl-2,3,3a,4,5,6,7,7a-octahydro-1H-indazole-5-carboxamide

MDL Number

MFCD00675051

FAQ

What are the physical and chemical properties of Adrenomedullin (AM) (13-52), human (CAS: 154765-05-6)?

Adrenomedullin (AM) (13-52), human, is a 30-amino acid peptide with a molecular weight of approximately 3500 Da. It is highly soluble in water and less soluble in organic solvents. The compound is stable under neutral to slightly alkaline conditions but can be degraded under acidic conditions. It exhibits low reactivity with common reagents.

How is Adrenomedullin (AM) (13-52), human (CAS: 154765-05-6) typically synthesized?

Adrenomedullin (AM) (13-52), human, is typically synthesized via solid-phase peptide synthesis (SPPS) using Fmoc chemistry. Commonly used protecting groups include Fmoc and Boc. The synthesis involves stepwise coupling of amino acids, followed by deprotection and purification, achieving a yield of around 70-80%.

What industries use Adrenomedullin (AM) (13-52), human (CAS: 154765-05-6)?

Adrenomedullin (AM) (13-52), human, is primarily used in the pharmaceutical industry for research on cardiovascular diseases and hypertension. It is also utilized in biotechnology for developing peptide-based therapeutic agents. Additionally, it has potential applications in the diagnostic industry for creating biomarker assays.

What precautions should be taken when handling Adrenomedullin (AM) (13-52), human (CAS: 154765-05-6)?

When handling Adrenomedullin (AM) (13-52), human, ensure the use of personal protective equipment (PPE), including gloves, goggles, and lab coats. Work in a well-ventilated area, preferably with a fume hood. Store the compound at -20°C to -80°C to maintain stability. In case of a spill, use appropriate cleanup materials and follow laboratory safety protocols. Refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.