Voltindole (Aceclofenac EP Impurity I, Diclofenac EP Impurity A, Diclofenac USP Related Compound A, Diclofenac Amide)

Basic Information

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CAS Number

15362-40-0

Molecular Formula

C14H9Cl2NO

Molecular Weight

278.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

125.0 to 129.0 deg-C

Boiling Point

488.6℃ at 760 mmHg

SMILES

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C1C2=CC=CC=C2N(C1=O)C3=C(C=CC=C3Cl)Cl

InChI

InChI=1S/C14H9Cl2NO/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(17)18/h1-7H,8H2

InChIKey

JCICIFOYVSPMHG-UHFFFAOYSA-N

LogP

4.214200000000003

Topological Polar Surface Area

20.310000000000002 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

326

Safety Information

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Hazard Statement

Stability

Synonyms & References

English

MLS000527383
N-(2,6-Dichlorophenyl)-2-indolinone
AM20060811
Diclofenac artifact
UPCMLD0ENAT5559022:001
1-(2,6-dichlorophenyl)-2-indolinone, AldrichCPR
1-(2,6-Dichlorophenyl)-2-indolinone
MFCD00451393
DICLOFENAC SODIUM IMPURITY A [EP IMPURITY]
D4260
ChemDiv3_002423
2-INDOLINONE, 1-(2,6-DICHLOROPHENYL)-
SR-01000457522-1
CHEMBL487716
1,3-Dihydro-1-(2,6-dichlorophenyl)-2H-indol-2-one
BRN 1538309
Diclofenac Amide
DTXCID4026979
Z57241954
BRD-K18569286-001-01-2
1-(2,6-Dichlorophenyl)indolin-2-one
AKOS000530778
CL5Y02756K
UNII-CL5Y02756K
SB64040
FT-0627229
1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one #
SY030556
1-(2,6-Dichlorophenyl)oxindole
Aceclofenac Impurity I
NCGC00256032-01

MDL Number

MFCD00451393

Customs Code

2933790090

FAQ

What is Voltindole (CAS: 15362-40-0)?

Voltindole, also known as Aceclofenac EP Impurity I, Diclofenac EP Impurity A, Diclofenac USP Related Compound A, and Diclofenac Amide, is a chemical compound with the CAS number 15362-40-0. It is primarily recognized as an impurity in nonsteroidal anti-inflammatory drugs (NSAIDs) such as aceclofenac and diclofenac. Voltindole is a white to off-white crystalline solid with a molecular formula of C15H13NO2S and a molecular weight of 275.32 g/mol. It is soluble in organic solvents and has a melting point around 164–166 °C.

What are the main uses of Voltindole (CAS: 15362-40-0)?

Voltindole is mainly used in the pharmaceutical industry as an impurity in NSAIDs like aceclofenac and diclofenac. It is also relevant in research for studying drug metabolism, impurity profiling, and quality control. Its presence in drug formulations is monitored to ensure safety and efficacy. Additionally, it may be used in analytical chemistry for standardization and method validation purposes.

Is Voltindole (CAS: 15362-40-0) safe?

Voltindole is generally considered safe when handled according to standard laboratory and pharmaceutical practices. However, as an impurity, its presence in drug products must be controlled to avoid potential adverse effects. It is recommended to use appropriate personal protective equipment (PPE) when working with Voltindole, and to follow safety guidelines related to chemical handling. Safety data sheets (SDS) should be consulted for detailed toxicity and exposure information.

How should Voltindole (CAS: 15362-40-0) be stored?

Voltindole should be stored in a cool, dry, and light-protected place, ideally at temperatures below 25 °C. It is best kept in a sealed container to prevent moisture absorption and contamination. Due to its chemical properties, it should be stored away from strong oxidizing agents and incompatible substances. Maintaining proper storage conditions ensures the stability and purity of Voltindole for analytical and pharmaceutical use.