Voltindole (Aceclofenac EP Impurity I, Diclofenac EP Impurity A, Diclofenac USP Related Compound A, Diclofenac Amide)(CAS: 15362-40-0)

Voltindole, also known as Aceclofenac EP Impurity I, Diclofenac EP Impurity A, Diclofenac USP Related Compound A, and Diclofenac Amide, is a chemical compound with the CAS number 15362-40-0. It is primarily recognized as an impurity in nonsteroidal anti-inflammatory drugs (NSAIDs) such as aceclofenac and diclofenac. Voltindole is a white to off-white crystalline solid with a molecular formula of C15H13NO2S and a molecular weight of 275.32 g/mol. It is soluble in organic solvents and has a melting point around 164–166 °C.

Voltindole is mainly used in the pharmaceutical industry as an impurity in NSAIDs like aceclofenac and diclofenac. It is also relevant in research for studying drug metabolism, impurity profiling, and quality control. Its presence in drug formulations is monitored to ensure safety and efficacy. Additionally, it may be used in analytical chemistry for standardization and method validation purposes.

Voltindole is generally considered safe when handled according to standard laboratory and pharmaceutical practices. However, as an impurity, its presence in drug products must be controlled to avoid potential adverse effects. It is recommended to use appropriate personal protective equipment (PPE) when working with Voltindole, and to follow safety guidelines related to chemical handling. Safety data sheets (SDS) should be consulted for detailed toxicity and exposure information.

Voltindole should be stored in a cool, dry, and light-protected place, ideally at temperatures below 25 °C. It is best kept in a sealed container to prevent moisture absorption and contamination. Due to its chemical properties, it should be stored away from strong oxidizing agents and incompatible substances. Maintaining proper storage conditions ensures the stability and purity of Voltindole for analytical and pharmaceutical use.