5-Fluoro-6-hydroxynicotinic acid

Basic Information

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CAS Number

1526-16-5

Molecular Formula

C6H4FNO3

Molecular Weight

157.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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C1=C(C(=O)NC=C1C(=O)O)F

InChI

InChI=1S/C6H4FNO3/c7-4-1-3(6(10)11)2-8-5(4)9/h1-2H,(H,8,9)(H,10,11)

InChIKey

IEXXBKVOINSOFC-UHFFFAOYSA-N

LogP

0.6244999999999998

Topological Polar Surface Area

70.42 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

280

Synonyms & References

English

5-fluoro-6-oxo-1,6-dihydro-3-pyridinecarboxylic Acid
5'-Fluor-5'-desoxy-cytidin
NSC524309
AG-F-36640
5'-fluoro-5'-deoxy-cytidine
5'-DEOXY-5-FLUOROCYTISINE
Cytidine,5'-deoxy-5'-fluoro- (6CI,7CI,8CI,9CI)
SureCN6673360
CTK4I0416
AC1L6ZHZ
5-fluoro-6-hydroxy-nicotinic acid
5-Fluor-6-hydroxy-nicotinsaeure
5-fluoro-6-hydroxynicotinic acid
IEXXBKVOINSOFC-UHFFFAOYSA-N
5-fluoro-6-hydroxypyridine-3-carboxylic acid
5-FLUORO-6-HYDROXYPYRIDINE-3-CARBOXYLIC ACID
E88354
SCHEMBL14333119
5-Fluoro-6-oxo-1,6-dihydropyridine-3-carboxylic Acid
5-fluoro-6-oxo-1H-pyridine-3-carboxylic acid
5-Fluoro-6-oxo-1,6-dihydropyridine-3-carboxylicacid
SY322837
5-Fluoro-6-hydroxynicotinicacid
EN300-106796
AKOS015969642
Z1255436475
DB-349921
AMY12521
KS-10458
MFCD13185870
1526-16-5

MDL Number

MFCD13185870

FAQ

What are the physical and chemical properties of 5-Fluoro-6-hydroxynicotinic acid (CAS: 1526-16-5)?

5-Fluoro-6-hydroxynicotinic acid is a crystalline solid with a molecular weight of approximately 171.03 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. This compound is relatively stable under normal conditions but can react with bases to form salts. It is also known to undergo hydrolysis in the presence of moisture.

How is 5-Fluoro-6-hydroxynicotinic acid (CAS: 1526-16-5) typically synthesized?

5-Fluoro-6-hydroxynicotinic acid is typically synthesized by the reduction of 5-fluoro-6-nitronicotinic acid followed by hydrolysis. This process involves using a reducing agent like sodium borohydride and a base such as sodium hydroxide. The reaction is carried out in an aqueous medium, and the product is isolated by crystallization.

What industries use 5-Fluoro-6-hydroxynicotinic acid (CAS: 1526-16-5)?

5-Fluoro-6-hydroxynicotinic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the development of chemical sensors and as a precursor in organic synthesis for the production of other fluorinated compounds. Additionally, it has applications in the polymer industry for modifying properties of polymers.

What precautions should be taken when handling 5-Fluoro-6-hydroxynicotinic acid (CAS: 1526-16-5) in the laboratory?

When handling 5-Fluoro-6-hydroxynicotinic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves and goggles, to prevent skin and eye contact. The compound should be stored in a cool, dry place, away from heat sources and incompatible materials. In case of a spill, it should be cleaned up using appropriate methods and materials. Refer to the Safety Data Sheet (SDS) for detailed safety information.