5-Fluoro-6-hydroxynicotinic acid(CAS: 1526-16-5)

5-Fluoro-6-hydroxynicotinic acid is a crystalline solid with a molecular weight of approximately 171.03 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. This compound is relatively stable under normal conditions but can react with bases to form salts. It is also known to undergo hydrolysis in the presence of moisture.

5-Fluoro-6-hydroxynicotinic acid is typically synthesized by the reduction of 5-fluoro-6-nitronicotinic acid followed by hydrolysis. This process involves using a reducing agent like sodium borohydride and a base such as sodium hydroxide. The reaction is carried out in an aqueous medium, and the product is isolated by crystallization.

5-Fluoro-6-hydroxynicotinic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the development of chemical sensors and as a precursor in organic synthesis for the production of other fluorinated compounds. Additionally, it has applications in the polymer industry for modifying properties of polymers.

When handling 5-Fluoro-6-hydroxynicotinic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves and goggles, to prevent skin and eye contact. The compound should be stored in a cool, dry place, away from heat sources and incompatible materials. In case of a spill, it should be cleaned up using appropriate methods and materials. Refer to the Safety Data Sheet (SDS) for detailed safety information.