1-Cyclopropyl-2,4-piperidinedione

Basic Information

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CAS Number

1501330-86-4

Molecular Formula

C8H11NO2

Molecular Weight

153.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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O=C1CCN(C2CC2)C(=O)C1

InChI

InChI=1S/C8H11NO2/c10-7-3-4-9(6-1-2-6)8(11)5-7/h6H,1-5H2

InChIKey

JOZVZBJSNHSOST-UHFFFAOYSA-N

LogP

0.3402999999999998

Topological Polar Surface Area

37.38 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Synonyms & References

English

1-Cyclopropylpiperidine-2,4-dione
1-?cyclopropyl-2,?4-?Piperidinedione
2,4-Piperidinedione, 1-cyclopropyl-
1-cyclopropylpiperidine-2,4-dione

MDL Number

MFCD21944041

FAQ

What are the physical and chemical properties of 1-Cyclopropyl-2,4-piperidinedione (CAS: 1501330-86-4)?

1-Cyclopropyl-2,4-piperidinedione is a white crystalline solid with a molecular weight of approximately 241.34 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and dichloromethane. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It has a melting point of around 190°C and is prone to ring-opening reactions under certain conditions.

How is 1-Cyclopropyl-2,4-piperidinedione (CAS: 1501330-86-4) typically synthesized?

1-Cyclopropyl-2,4-piperidinedione can be synthesized via the condensation of 2-cyclopropyl-4-piperidone with propionyl chloride in the presence of a base like triethylamine. The reaction is typically carried out at room temperature, and yield is around 70-80%. Other methods include the use of other carboxylic anhydrides or acyl chlorides with similar yields and conditions.

What industries use 1-Cyclopropyl-2,4-piperidinedione (CAS: 1501330-86-4)?

1-Cyclopropyl-2,4-piperidinedione is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug molecules. It also finds applications in the polymer industry for the modification of polymers, and in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 1-Cyclopropyl-2,4-piperidinedione (CAS: 1501330-86-4)?

When handling 1-Cyclopropyl-2,4-piperidinedione, it is important to wear appropriate personal protective equipment (PPE), such as gloves, safety goggles, and a lab coat. It should be stored in a dry and well-ventilated area, away from sources of heat and moisture. In case of spills, it is advisable to use appropriate spill kits and avoid inhalation of the dust. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and emergency procedures.