1-Cyclopropyl-2,4-piperidinedione(CAS: 1501330-86-4)

1-Cyclopropyl-2,4-piperidinedione is a white crystalline solid with a molecular weight of approximately 241.34 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and dichloromethane. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It has a melting point of around 190°C and is prone to ring-opening reactions under certain conditions.

1-Cyclopropyl-2,4-piperidinedione can be synthesized via the condensation of 2-cyclopropyl-4-piperidone with propionyl chloride in the presence of a base like triethylamine. The reaction is typically carried out at room temperature, and yield is around 70-80%. Other methods include the use of other carboxylic anhydrides or acyl chlorides with similar yields and conditions.

1-Cyclopropyl-2,4-piperidinedione is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug molecules. It also finds applications in the polymer industry for the modification of polymers, and in the development of sensors and semiconductors due to its unique chemical properties.

When handling 1-Cyclopropyl-2,4-piperidinedione, it is important to wear appropriate personal protective equipment (PPE), such as gloves, safety goggles, and a lab coat. It should be stored in a dry and well-ventilated area, away from sources of heat and moisture. In case of spills, it is advisable to use appropriate spill kits and avoid inhalation of the dust. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and emergency procedures.