Sacubitril | CAS No. 149709-62-6

Sacubitril

Basic Information

View in Editor

CAS Number

149709-62-6

Molecular Formula

C24H29NO5

Molecular Weight

411.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

656.9±55.0°C at 760 mmHg

SMILES

View in Editor

CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O

InChI

InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1

InChIKey

PYNXFZCZUAOOQC-UTKZUKDTSA-N

LogP

3.8350000000000017

Topological Polar Surface Area

92.7 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

550

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AHU-377
4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-Methyl-5-oxopentan-2-yl)aMino)-4-oxobutanoic acid
4-(((2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-Methyl-5-oxopentan-2-yl)aMino)-4-oxobutanoic acid
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid
4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid
AHU 377
AHU-?377
Sacubitril
Sacubitril-D4
LCZ696 Intermediate3
Valsartan
(2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester
LCZ697
AHU-77
Sacubitril API
Sacubtril(LCZ696)
LCZ-696 Impurity 3
Sacubitril(AHU-377)
Sacubitril Related Compound 1
Entresto( sacubitril+ valsartan)
4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
[1,1'-Biphenyl]-4-pentanoic acid, gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-, alpha-ethyl ester, (alphaR,gammaS)-
ENTRESTO COMPONENT SACUBITRIL
sucabitril
AKOS027321509
AM85599
SACUBITRIL [JAN]
CHEBI:134714
AC-28899
EN300-303419
Q17811448

MDL Number

MFCD00920862

FAQ

What is Sacubitril (CAS: 149709-62-6)?

Sacubitril is a pharmaceutical compound with the CAS number 149709-62-6. It is a neprilysin inhibitor used primarily in the treatment of heart failure. Chemically, it is known as 4-[[3-[[[2-(2-ethoxyethoxy)ethoxy]methoxy]methyl]amino]propyl]benzenesulfonamide. Sacubitril is a white to off-white solid with good solubility in water and is stable under normal storage conditions.

What are the main uses of Sacubitril (CAS: 149709-62-6)?

Sacubitril is mainly used in the pharmaceutical industry as a medication for heart failure, particularly in combination with valsartan. It works by inhibiting the enzyme neprilysin, which helps improve cardiac function and reduce symptoms. Additionally, it is used in research for studying the effects of neprilysin inhibition on cardiovascular health and related conditions.

Is Sacubitril (CAS: 149709-62-6) safe?

Sacubitril is considered safe when used as directed in medical treatment. It has been approved by regulatory agencies for use in heart failure management. However, like all medications, it should be handled with care, and healthcare professionals should monitor for potential side effects. Proper storage and adherence to safety guidelines are essential to maintain its efficacy and safety profile.

How should Sacubitril (CAS: 149709-62-6) be stored?

Sacubitril should be stored in a cool, dry place away from direct light. It is typically kept in a sealed container at a temperature between 15°C and 25°C. Maintaining proper humidity levels is important to prevent degradation. Always store the compound in a secure location to avoid contamination and ensure stability over time.