tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate | CAS No. 148214-90-8
tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate
Basic Information
CAS Number
148214-90-8
Molecular Formula
C9H18N2O3
Molecular Weight
202.25 g/mol
AD
Chemical Classification
Basic Physical Properties
Physical State
White to Yellow Solid
Boiling Point
308.8°C at 760 mmHg
Safety Information
View Safety InformationHazard Statement
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Hazard Class
Class IRRITANT
Class IRRITANT
Synonyms & References
English
- AMY6784
- 1-PYRROLIDINECARBOXYLIC ACID, 3-AMINO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3R,4R)-REL-
- BB 0261102
- CHEMBL4542210
- (3R,4R)- 3-Amino-4-hydroxy-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester
- 1-Boc-(3R,4R)-3-amino-4-hydroxypyrrolidine
- tert-butyl(3R*,4R*)-3-amino-4-hydroxy-pyrrolidine-1-carboxylate
- CS-WAA0305
- rac-tert-butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate
- tert-butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate
- (3R,4R)-TERT-BUTYL 3-AMINO-4-HYDROXYPYRROLIDINE-1-CARBOXYLATE
- (3R,4R)-rel-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate
- (3R,4R)-1-BOC-3-AMINO-4-HYDROXY-PYRROLIDINE
- tert-Butyl trans-3-amino-4-hydroxypyrrolidine-1-carboxylate
- AKOS015854201
- F6545-4035
- MOZOQDNRVPHFOO-RNFRBKRXSA-N
- tert-Butyl (3R,4R)-3-amino-4-hydroxy-pyrrolidine-1-carboxylate
- (3R,4R)-tert-butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
- TRANS-TERT-BUTYL 3-AMINO-4-HYDROXYPYRROLIDINE-1-CARBOXYLATE
- MFCD11111251
- trans-1-Boc-3-aminohydroxypyrrolidin-4-ol
- DS-8649
- A875444
- trans-3-Amino-1-Boc-4-hydroxypyrrolidine
- 330681-18-0
- W13258
- (3R,4R)-3-amino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
- (3R,4R)-3-Amino-4-hydroxy-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester
- (3R,4R)-1-Boc-3-amino-4-hydroxypyrrolidine
- SCHEMBL344451
MDL Number
MFCD06858457
Customs Code
2933990090
FAQ
What are the physical and chemical properties of tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate (CAS: 148214-90-8)?
Tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate is a white crystalline solid with a molecular weight of approximately 240.35 g/mol. It has a pKa of around 8.5, indicating basic behavior. The compound is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. It is known to be reactive towards nucleophiles and can undergo substitution and condensation reactions.
How is tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate (CAS: 148214-90-8) typically synthesized?
Tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate is typically synthesized via a multistep process involving the formation of a protected pyrrolidine followed by amidation. The synthesis often requires the use of a protecting group, such as tert-butyloxycarbonyl (Boc), and can be carried out using standard chemical methods with good yield and selectivity under mild conditions.
What industries use tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate (CAS: 148214-90-8)?
Tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate finds applications in the pharmaceutical industry for its use as a precursor in the synthesis of drugs. It is also utilized in the polymer industry for functionalization of polymers and in the production of sensor materials due to its amino and hydroxyl functionalities.
What precautions should be taken when handling tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate (CAS: 148214-90-8)?
When handling tert-butyl trans-3-amino-4-hydroxy-pyrrolidine-1-carboxylate, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be rinsed with water. Always consult a safety data sheet (SDS) for detailed handling and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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