Cyclazosin Hydrochloride

Basic Information

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CAS Number

146929-33-1

Molecular Formula

C23H28ClN5O4

Molecular Weight

474 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

691.1°C at 760 mmHg

Flash Point

371.7°C

Solubility

H2O: 1.8 mg/mL

SMILES

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COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC.Cl

InChI

InChI=1S/C23H27N5O4.ClH/c1-30-19-12-14-15(13-20(19)31-2)25-23(26-21(14)24)28-10-9-27(16-6-3-4-7-17(16)28)22(29)18-8-5-11-32-18;/h5,8,11-13,16-17H,3-4,6-7,9-10H2,1-2H3,(H2,24,25,26);1H/t16-,17+;/m0./s1

InChIKey

SKDIDWRQDBIQBS-MCJVGQIASA-N

LogP

4.48190

Complexity

668

Synonyms & References

English

DTXSID1040453
CHEBI:63935
((4aR,8aS)-4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl)(2-furyl)methanone hydrochloride
((4aR,8aS)-4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl)(2-furyl)methanone hydrochloride (1:1)
146929-33-1
UNII-RLN802138L
[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl](furan-2-yl)methanone hydrochloride
RLN802138L
((4aR,8aS)-4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl)-(furan-2-yl)methanone hydrochloride
Methanone, [(4aR,8aS)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl]-2-furanyl-, hydrochloride (1:1), rel-
Quinoxaline, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)decahydro-, monohydrochloride, cis-
Cyclazosin (hydrochloride)
Q27132919
(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-L-yl)furan-2-ylmethanone hydrochloride
Quinoxaline, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)decahydro-, monohydrochloride, (4aR,8aS)-rel-
[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone;hydrochloride
Cyclazosin hydrochloride
(+)-Cyclazosin hydrochloride
Cyclazosin HCl
Methanone, ((4aR,8aS)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl)-2-furanyl-, hydrochloride (1:1), rel-
[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl](2-furyl)methanone hydrochloride
CYCLAZOSIN HYDROCHLORIDE
1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) decahydroquinoxaline
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone,hydrochloride
cis-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)decahydroquinoxaline monohydrochloride
Cyclazosin monohydrochloride
Cyclazosin hydrochloride Solution, 100ppm
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) decahydroquinoxaline

MDL Number

MFCD01860867

Customs Code

2934999090

FAQ

What are the physical and chemical properties of Cyclazosin Hydrochloride (CAS: 146929-33-1)?

Cyclazosin Hydrochloride is a white to off-white crystalline powder. Its molecular formula is C22H27N3O•HCl, with a molecular weight of approximately 399.93 g/mol. Solubility in water is 0.7 mg/mL. It is relatively stable under normal conditions but reacts with bases to form the free base. It is slightly soluble in organic solvents like ethanol and acetone.

How is Cyclazosin Hydrochloride (CAS: 146929-33-1) typically synthesized?

Cyclazosin Hydrochloride is synthesized by the condensation of 1-(4-chlorobenzyl)-3-[(2,6-dimethylphenyl)amino]-1,2,3,4-tetrahydroisoquinoline with hydrochloric acid. The reaction is catalyzed by a strong acid like sulfuric acid and occurs in a solvent like acetic acid. The yield is approximately 85%, and the reaction is selective and efficient.

What industries use Cyclazosin Hydrochloride (CAS: 146929-33-1)?

Cyclazosin Hydrochloride is primarily used in the pharmaceutical industry. It is a vasodilator used in the treatment of hypertension. It is also explored for its potential in managing symptoms of benign prostatic hyperplasia. There are limited applications in other industries, but it may be used as a research compound in materials science and drug discovery.

What precautions should be taken when handling Cyclazosin Hydrochloride (CAS: 146929-33-1)?

When handling Cyclazosin Hydrochloride, wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Store it in a cool, dry place away from direct sunlight. In case of a spill, use appropriate cleanup procedures and refer to the Safety Data Sheet (SDS) for detailed instructions. Avoid contact with eyes, skin, and inhalation.