Cyclazosin Hydrochloride(CAS: 146929-33-1)

Cyclazosin Hydrochloride is a white to off-white crystalline powder. Its molecular formula is C22H27N3O•HCl, with a molecular weight of approximately 399.93 g/mol. Solubility in water is 0.7 mg/mL. It is relatively stable under normal conditions but reacts with bases to form the free base. It is slightly soluble in organic solvents like ethanol and acetone.

Cyclazosin Hydrochloride is synthesized by the condensation of 1-(4-chlorobenzyl)-3-[(2,6-dimethylphenyl)amino]-1,2,3,4-tetrahydroisoquinoline with hydrochloric acid. The reaction is catalyzed by a strong acid like sulfuric acid and occurs in a solvent like acetic acid. The yield is approximately 85%, and the reaction is selective and efficient.

Cyclazosin Hydrochloride is primarily used in the pharmaceutical industry. It is a vasodilator used in the treatment of hypertension. It is also explored for its potential in managing symptoms of benign prostatic hyperplasia. There are limited applications in other industries, but it may be used as a research compound in materials science and drug discovery.

When handling Cyclazosin Hydrochloride, wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Store it in a cool, dry place away from direct sunlight. In case of a spill, use appropriate cleanup procedures and refer to the Safety Data Sheet (SDS) for detailed instructions. Avoid contact with eyes, skin, and inhalation.