Methyl 2-aminonicotinate

Basic Information

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CAS Number

14667-47-1

Molecular Formula

C7H8N2O2

Molecular Weight

152.15 g/mol

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

82.0 to 86.0 deg-C

Boiling Point

251.3℃ at 760 mmHg

Density

1.238

Flash Point

105.8℃

Refractive Index

1.57

SMILES

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COC(=O)C1=C(N=CC=C1)N

InChI

InChI=1S/C7H8N2O2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3,(H2,8,9)

InChIKey

NZZDEODTCXHCRS-UHFFFAOYSA-N

LogP

0.4504

Topological Polar Surface Area

65.21 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

149

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Amino-nicotinic acid methyl ester
CS-M1170
2-Aminonicotinic Acid Methyl Ester
METHYL2-AMINONICOTINATE
InChI=1/C7H8N2O2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3,(H2,8,9)
W-205641
Z18385460
M2125
BP-11927
SY007227
Aminonicotinsauremethylester
Methyl 2-amino-3-pyridine carboxylate
EN300-69947
SB33717
NSC-522516
AC-3584
3-Pyridinecarboxylic acid, 2-amino-, methyl ester
HY-76735
MFCD00128872
(S)-4-(TERT-BUTOXYCARBONYL)MORPHOLINE-2-CARBOXYLICACID
BCP11523
DTXSID70325994
NSC522516
AM20070284
9P-032
SR-01000538272
FT-0650114
SR-01000538272-1
2-aminonicotinic acid methylester
methyl 2-amino-pyridine-3-carboxylate
Methyl 2-aminopyridine-3-carboxylate, 97%

MDL Number

MFCD00128872

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Methyl 2-aminonicotinate (CAS: 14667-47-1)?

Methyl 2-aminonicotinate (CAS: 14667-47-1) is a crystalline solid with a molecular weight of approximately 176.24 g/mol. It has a solubility of about 3.8 g/L in water. It is moderately reactive, particularly in acidic conditions. The compound is stable under normal storage conditions but should be protected from moisture and strong bases.

How is Methyl 2-aminonicotinate (CAS: 14667-47-1) typically synthesized?

Methyl 2-aminonicotinate is typically synthesized by reacting nicotinoyl chloride with methylamine in the presence of a base such as sodium hydroxide. The reaction produces a mixture that can be purified by recrystallization or distillation. The yield is around 75-85%, and the process is selective and efficient.

What industries use Methyl 2-aminonicotinate (CAS: 14667-47-1)?

Methyl 2-aminonicotinate is used in various industries, including pharmaceuticals for the synthesis of certain drugs, and as an intermediate in the production of dyes and pigments. It is also used in research for its reactivity and functionality in chemical reactions.

What precautions should be taken when handling Methyl 2-aminonicotinate (CAS: 14667-47-1)?

When handling Methyl 2-aminonicotinate (CAS: 14667-47-1), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle in a fume hood to avoid inhalation. Store it in a cool, dry place away from moisture and strong bases. In case of spill, use appropriate absorbents and consult the Safety Data Sheet (SDS) for detailed instructions.