Methyl 2-aminonicotinate(CAS: 14667-47-1)

Methyl 2-aminonicotinate (CAS: 14667-47-1) is a crystalline solid with a molecular weight of approximately 176.24 g/mol. It has a solubility of about 3.8 g/L in water. It is moderately reactive, particularly in acidic conditions. The compound is stable under normal storage conditions but should be protected from moisture and strong bases.

Methyl 2-aminonicotinate is typically synthesized by reacting nicotinoyl chloride with methylamine in the presence of a base such as sodium hydroxide. The reaction produces a mixture that can be purified by recrystallization or distillation. The yield is around 75-85%, and the process is selective and efficient.

Methyl 2-aminonicotinate is used in various industries, including pharmaceuticals for the synthesis of certain drugs, and as an intermediate in the production of dyes and pigments. It is also used in research for its reactivity and functionality in chemical reactions.

When handling Methyl 2-aminonicotinate (CAS: 14667-47-1), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle in a fume hood to avoid inhalation. Store it in a cool, dry place away from moisture and strong bases. In case of spill, use appropriate absorbents and consult the Safety Data Sheet (SDS) for detailed instructions.