2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate

Basic Information

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CAS Number

146667-84-7

Molecular Formula

C12H23NO3

Molecular Weight

229.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Colorless to Yellow Liquid

Boiling Point

324℃ at 760 mmHg

Flash Point

149.79℃

SMILES

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CC(C)(C)OC(=O)N1CCCC(C1)CCO

InChI

InChI=1S/C12H23NO3/c1-12(2,3)16-11(15)13-7-4-5-10(9-13)6-8-14/h10,14H,4-9H2,1-3H3

InChIKey

DXABICKZWDHPIP-UHFFFAOYSA-N

LogP

2.0159000000000002

Topological Polar Surface Area

49.769999999999996 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

235

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AB29458
DTXSID40439633
Tert-butyl3-(2-hydroxyethyl)piperidine-1-carboxylate
MFCD04114970
(R)-tert-Butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate; (R)-3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester
Q-102997
1-N-Boc-piperidine-3-ethanol
SY002824
SCHEMBL771181
3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester
EN300-61996
1-Piperidinecarboxylicacid, 3-(2-hydroxyethyl)-, 1,1-dimethylethyl ester
FT-0648139
A13561
PB21853
CS-WAA0064
(r)-1-n-boc-3-(2-hydroxyethyl)piperidine
CS-W001853
DS-10754
tert-Butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate; 3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester
N-BOC-3-(2-HYDROXYETHYL)PIPERIDINE
FT-0770422
FT-0773265
AB29456
Tert-butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate
N-tert-butoxycarbonyl-3-(2-hydroxyethyl)piperidine
1-PIPERIDINECARBOXYLIC ACID, 3-(2-HYDROXYETHYL)-, 1,1-DIMETHYLETHYL ESTER
A13559
DXABICKZWDHPIP-UHFFFAOYSA-N
3-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
1-boc-3-(2-hydroxy-ethyl)-piperidine

MDL Number

MFCD04114970

FAQ

What are the physical and chemical properties of 2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate (CAS: 146667-84-7)?

2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate is a colorless to white crystalline solid with a molecular weight of approximately 251.36 g/mol. It is slightly soluble in water and miscible with organic solvents. Chemically, it is reactive towards bases and can undergo ester hydrolysis under certain conditions. It is also known for its amphoteric nature and ability to form salts.

How is 2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate (CAS: 146667-84-7) typically synthesized?

2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate is typically synthesized via an esterification reaction between 2-methyl-2-propanol and 3-(2-hydroxyethyl)-1-piperidinecarboxylic acid. This process involves the use of an acid catalyst and is performed at a controlled temperature to ensure high yield and selectivity. The reaction is exothermic and requires careful temperature control to avoid side reactions.

What industries use 2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate (CAS: 146667-84-7)?

2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate is primarily used in the pharmaceutical and cosmetic industries due to its chemical structure and reactivity. It serves as a starting material for the synthesis of various drugs and as a functional group for modifying other molecules. Additionally, it finds applications in the polymer industry for the development of specialty polymers.

What precautions should be taken when handling 2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate (CAS: 146667-84-7)?

When handling 2-Methyl-2-propanyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be stored in a cool, dry place away from heat sources and incompatible materials. In the event of a spill, it should be handled according to standard laboratory procedures, and the Material Safety Data Sheet (MSDS) should be referenced for specific guidance. Good laboratory practices and fume hood use are recommended to ensure safety.