Alvocidib (Flavopiridol)

Basic Information

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CAS Number

146426-40-6

Molecular Formula

C21H20ClNO5

Molecular Weight

401.85 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

603.6±55.0°C at 760 mmHg

SMILES

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CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

InChI

InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1

InChIKey

BIIVYFLTOXDAOV-YVEFUNNKSA-N

LogP

3.3046000000000024

Topological Polar Surface Area

94.14 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

628

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

L 868275
L86-8275
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
(-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
SCHEMBL3652
MFCD20501884
Alvocidib [USAN]
Alvocidib
1c8k
Flavopiridol HCl; Alvocidib
L868275
BRD-K87909389-001-01-2
FLAVO
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, cis-(-)-
1e1y
Alvocidib (USAN/INN)
NSC-799330
FLAVOPIRIDOL [MI]
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
BDBM5655
ALVOCIDIB [WHO-DD]
HY-10005
DB03496
MDL-107826A
Flavoperidol
Alvocidib [USAN:INN]
CCG-268666
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-2,3-dihydro-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
NSC799330
D09868
A25160

MDL Number

MFCD20501884

FAQ

What are the physical and chemical properties of Alvocidib (CAS: 146426-40-6)?

Alvocidib (CAS: 146426-40-6) is a water-soluble compound with a molecular weight of approximately 404.28 g/mol. Its crystalline form exhibits good stability at room temperature. It is moderately reactive with some nucleophiles, making it suitable for certain synthetic transformations.

How is Alvocidib (CAS: 146426-40-6) typically synthesized?

Alvocidib (CAS: 146426-40-6) is synthesized through a multi-step process involving condensation, reduction, and acylation reactions. The synthesis often uses catalytic amounts of palladium and other transition metals, with yields typically ranging from 50-70%.

What industries use Alvocidib (CAS: 146426-40-6)?

Alvocidib (CAS: 146426-40-6) is primarily used in the pharmaceutical industry for its antiproliferative and antitumor activities. It is also explored in research and development for its potential in other applications such as polymer synthesis and sensing technologies.

What precautions should be taken when handling Alvocidib (CAS: 146426-40-6)?

When handling Alvocidib (CAS: 146426-40-6), ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated fume hood to avoid inhalation risks. Always refer to the Safety Data Sheet (SDS) for detailed spill and disposal instructions.