(1R)-1-(5-Fluoro-2-iodophenyl)ethanol

Basic Information

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CAS Number

1454852-98-2

Molecular Formula

C8H8FIO

Molecular Weight

266.05 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

275.7±30.0 °C(Predicted)

Density

1.812±0.06 g/cm3(Predicted)

SMILES

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Fc1ccc(c(c1)[C@H](O)C)I

InChI

InChI=1S/C8H8FIO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-5,11H,1H3/t5-/m1/s1

InChIKey

GQGBQRLYBYFVAW-RXMQYKEDSA-N

LogP

2.483600000000001

pKa

13.80±0.20(Predicted)

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Synonyms & References

English

(R)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
Benzenemethanol, 5-fluoro-2-iodo-α-methyl-, (αR)-
EOS-60595
(R)-1-(5-Fluoro-2-iodophenyl)ethanol
Benzenemethanol, 5-fluoro-2-iodo-α-methyl-, (αR)-

MDL Number

MFCD30802286

FAQ

What are the physical and chemical properties of (1R)-1-(5-Fluoro-2-iodophenyl)ethanol (CAS: 1454852-98-2)?

(1R)-1-(5-Fluoro-2-iodophenyl)ethanol is a colorless to light yellow liquid with a molecular weight of approximately 309.97 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is relatively stable but can react with reducing agents. It is used as an intermediate in organic synthesis.

How is (1R)-1-(5-Fluoro-2-iodophenyl)ethanol (CAS: 1454852-98-2) typically synthesized?

(1R)-1-(5-Fluoro-2-iodophenyl)ethanol can be synthesized via the reaction of 2-iodo-5-fluorobenzaldehyde with ethanol. The reaction is typically catalyzed by a base like sodium ethoxide. The yield is around 70-80%, and the product is isolated by recrystallization. The reaction is selective and efficient for this specific compound.

What industries use (1R)-1-(5-Fluoro-2-iodophenyl)ethanol (CAS: 1454852-98-2)?

(1R)-1-(5-Fluoro-2-iodophenyl)ethanol is primarily used in the pharmaceutical industry as an intermediate for synthesizing various drugs. It can also be used in polymer chemistry for developing new materials and in the field of chemical sensors for detecting specific compounds.

What precautions should be taken when handling (1R)-1-(5-Fluoro-2-iodophenyl)ethanol (CAS: 1454852-98-2)?

When handling (1R)-1-(5-Fluoro-2-iodophenyl)ethanol, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure the use of a fume hood during the handling of the compound. In case of a spill, neutralize any potential reaction products and clean up with appropriate chemicals. Refer to the Safety Data Sheet (SDS) for detailed guidelines and emergency procedures.