1-(5-Bromo-2-hydroxyphenyl)ethanone

Basic Information

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CAS Number

1450-75-5

Molecular Formula

C8H7BrO2

Molecular Weight

215.05 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

56.0 to 60.0 deg-C

Boiling Point

282.6 °C at 760 mmHg

Density

1.586

Flash Point

124.7 °C

Solubility

Soluble in Chloroform

Refractive Index

1.591

SMILES

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CC(=O)C1=C(C=CC(=C1)Br)O

InChI

InChI=1S/C8H7BrO2/c1-5(10)7-4-6(9)2-3-8(7)11/h2-4,11H,1H3

InChIKey

HQCCNFFIOWYINW-UHFFFAOYSA-N

LogP

2.357300000000001

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

158

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

1-(5-bromo-2-hydroxyphenyl)ethan-1-one
Z104500026
CS-W007495
AB04623
SCHEMBL309016
FS-1294
5'-Bromo-2'-hydroxyacetophenone
Ethanone, 1-(5-bromo-2-hydroxyphenyl)-
1450-75-5
BRN 2045140
DTXSID50162864
1-(5-Bromo-2-hydroxyphenyl)ethanone
5-bromo-2-hydroxy acetophenone
MFCD00191850
SY018236
2'-Hydroxy-5'-bromoacetophenone
AC-8266
CK2552
5 inverted exclamation mark -Bromo-2 inverted exclamation mark -hydroxyacetophenone
1-(5-bromo-2-hydroxyphenyl)-ethanone
NS00024719
J-200077
FT-0633556
5-bromo-2-hydroxyacetophenone
Acetophenone, 5'-bromo-2'-hydroxy- (6CI,7CI,8CI)
EN300-21489
NSC46621
A21054
2-Acetyl-4-bromophenol
4-08-00-00328 (Beilstein Handbook Reference)
2-hydroxy-5-bromoacetophenone

MDL Number

MFCD00191850

Customs Code

2914700090

FAQ

What are the physical and chemical properties of 1-(5-Bromo-2-hydroxyphenyl)ethanone (CAS: 1450-75-5)?

1-(5-Bromo-2-hydroxyphenyl)ethanone is a crystalline solid with a molecular weight of approximately 265.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is reactive towards nucleophiles and can undergo substitution reactions. It is used in organic synthesis and as an intermediate in the production of other compounds.

How is 1-(5-Bromo-2-hydroxyphenyl)ethanone (CAS: 1450-75-5) typically synthesized?

1-(5-Bromo-2-hydroxyphenyl)ethanone can be synthesized via the bromination of 2-hydroxyacetophenone followed by condensation with bromophenol. The reaction is typically catalyzed by a Lewis acid like aluminium trichloride. Yields are moderate, and the reaction is highly selective for the desired bromo compound.

What industries use 1-(5-Bromo-2-hydroxyphenyl)ethanone (CAS: 1450-75-5)?

1-(5-Bromo-2-hydroxyphenyl)ethanone is used in the pharmaceutical industry for the synthesis of various drugs. It also finds applications in the synthesis of materials for sensors and as an intermediate in the production of certain polymers. Its use in semiconductors is less common but still relevant for specific applications.

What precautions should be taken when handling 1-(5-Bromo-2-hydroxyphenyl)ethanone (CAS: 1450-75-5)?

When handling 1-(5-Bromo-2-hydroxyphenyl)ethanone, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or fume hood to prevent inhalation of fumes. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be washed down. Always refer to the Safety Data Sheet (SDS) for specific emergency procedures and disposal instructions.