1-(5-Bromo-2-hydroxyphenyl)ethanone(CAS: 1450-75-5)

1-(5-Bromo-2-hydroxyphenyl)ethanone is a crystalline solid with a molecular weight of approximately 265.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is reactive towards nucleophiles and can undergo substitution reactions. It is used in organic synthesis and as an intermediate in the production of other compounds.

1-(5-Bromo-2-hydroxyphenyl)ethanone can be synthesized via the bromination of 2-hydroxyacetophenone followed by condensation with bromophenol. The reaction is typically catalyzed by a Lewis acid like aluminium trichloride. Yields are moderate, and the reaction is highly selective for the desired bromo compound.

1-(5-Bromo-2-hydroxyphenyl)ethanone is used in the pharmaceutical industry for the synthesis of various drugs. It also finds applications in the synthesis of materials for sensors and as an intermediate in the production of certain polymers. Its use in semiconductors is less common but still relevant for specific applications.

When handling 1-(5-Bromo-2-hydroxyphenyl)ethanone, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or fume hood to prevent inhalation of fumes. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be washed down. Always refer to the Safety Data Sheet (SDS) for specific emergency procedures and disposal instructions.