Landiolol hydrochloride

Basic Information

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CAS Number

144481-98-1

Molecular Formula

C25H40ClN3O8

Molecular Weight

546.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

124.0 to 128.0 deg-C

Boiling Point

727.5°Cat760mmHg

Density

1.201

Flash Point

393.8°C

SMILES

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CC1(OCC(O1)COC(=O)CCC2=CC=C(C=C2)OCC(CNCCNC(=O)N3CCOCC3)O)C.Cl

InChI

InChI=1S/C25H39N3O8.ClH/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28;/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31);1H/t20-,22+;/m0./s1

InChIKey

DLPGJHSONYLBKP-IKGOIYPNSA-N

LogP

1.106800000000001

Topological Polar Surface Area

127.82000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 11

Complexity

666

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Toxicity

LD50 in mice (mg/kg): 290 i.v. (Iguchi)

Synonyms & References

English

Landiolol HCl
L0296
MFCD01937430
UNII-G8HQ634Y17
Onoact
Landiolol (hydrochloride)
A808219
D01847
Landiolol hydrochloride
ONO-1101 hydrochloride
CHEBI:31760
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate;hydrochloride
((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate HCl
CAS-144481-98-1
Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, hydrochloride (1:1)
ONO1101 (hydrochloride)
((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate hydrochloride
G8HQ634Y17
Landiolol hydrochloride [USAN]
Landiolol hydrochloride (JAN)
LANDIOLOL HYDROCHLORIDE [MART.]
Landiolol
AC-22604
LANDIOLOL HYDROCHLORIDE [JAN]
ONO 1101;ONO-1101;ONO1101
DTXSID3048605
144481-98-1
ONO 1101 hydrochloride
NCGC00182709-02
Onoact (TN)
Tox21_112940

MDL Number

MFCD01937430

FAQ

What is landiolol hydrochloride (CAS: 144481-98-1)?

Landinolol hydrochloride is a selective beta1-adrenergic receptor antagonist used in the treatment of arrhythmias and hypertension. It has a molecular formula of C18H30ClN2O2S and a molecular weight of 377.86. This compound is known for its cardiovascular benefits and is often used in clinical settings due to its specific pharmacological profile.

What are the main uses of landiolol hydrochloride (CAS: 144481-98-1)?

Landinolol hydrochloride is primarily used in the management of various cardiac conditions, including supraventricular tachycardia, atrial fibrillation, and acute heart failure. It is also used in cardiac surgery to prevent arrhythmias and manage postoperative hypertension.

Is landiolol hydrochloride (CAS: 144481-98-1) safe?

Landinolol hydrochloride is generally safe when used under medical supervision. However, it is important to follow prescribed dosages and monitoring protocols to minimize potential side effects such as bradycardia, hypotension, and bronchospasm. Patients with a history of asthma or severe heart failure should use this compound with caution.

How should landiolol hydrochloride (CAS: 144481-98-1) be stored?

Landinolol hydrochloride should be stored at a temperature not exceeding 25°C (77°F). Keep the compound away from moisture and direct sunlight. Store it in a tightly sealed container to prevent degradation. It is advisable to keep the medication in a cool, dry place and ensure it is out of reach of children and pets.