N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide

Basic Information

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CAS Number

144222-34-4

Molecular Formula

C21H22N2O2S

Molecular Weight

366.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

128.0 to 131.0 deg-C

Boiling Point

537.3±60.0 °C at 760 mmHg

Density

1.1440 (rough estimate)

Flash Point

278.8℃

Refractive Index

-30 ° (C=0.4, CHCl3)

Specific Rotation

-61.5 º (c=1, CH2Cl2)

SMILES

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CC1=CC=C(C=C1)S(=O)(=O)NC(C2=CC=CC=C2)C(C3=CC=CC=C3)N

InChI

InChI=1S/C21H22N2O2S/c1-16-12-14-19(15-13-16)26(24,25)23-21(18-10-6-3-7-11-18)20(22)17-8-4-2-5-9-17/h2-15,20-21,23H,22H2,1H3/t20-,21-/m1/s1

InChIKey

UOPFIWYXBIHPIP-NHCUHLMSSA-N

LogP

3.714620000000002

Topological Polar Surface Area

72.19 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

511

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CS-W002878
(1R,2R)-(-)-(4-toluenesulfonyl)-1,2-diphenylethylenediamine
TsDPEN
C21H22N2O2S
Benzenesulfonamide, N-[(1R,2R)-2-amino-1,2-diphenylethyl]-4-methyl-
DTXSID70370363
(1r,2r)-n-p-tosyl-1,2-diphenylethylenediamine
144222-34-4
(R,R)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine
CBiol_000201
AC-3419
MFCD02093428
(1R,2R)-(-)-N-(4-toluene sulfonyl)-1,2-diphenyl ethylene diamine
N-[(1R,2R)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide
HY-W002878
(1R,2R)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine
(R,R)-TSDPEN
N-[(1R,2R)-2-AMINO-1,2-DIPHENYLETHYL]-4-METHYLBENZENE-1-SULFONAMIDE
AKOS015897291
(r,r)-n-(p-toluenesulfonyl)-1,2-diphenylethanediamine
SCHEMBL258422
A3126
(1R, 2R)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine
224454-16-4
N-((1R,2R)-2-AMINO-1,2-DIPHENYLETHYL)-4-METHYLBENZENESULFONAMIDE
UOPFIWYXBIHPIP-NHCUHLMSSA-N
ICCB2_000201
(R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylendiamine
AS-11921
(R,R)-N-(2-Amino-1,2-diphenylethyl)-p-toluenesulfonamide
rel-N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide

MDL Number

MFCD02093428

Customs Code

2935009090

FAQ

What are the physical and chemical properties of N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide (CAS: 144222-34-4)?

N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide is a white crystalline solid with a molecular weight of approximately 432.4 g/mol. It has a low solubility in water and moderate solubility in organic solvents. The compound is relatively stable but susceptible to hydrolysis in acidic or basic conditions. It does not show significant reactivity towards common functional groups under normal conditions.

How is N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide (CAS: 144222-34-4) typically synthesized?

N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide is synthesized via multi-step organic synthesis involving the preparation of the amino-substituted phenyl ethylamine followed by sulfonamide formation with 4-methylbenzenesulfonyl chloride. The reaction typically requires a phase-transfer catalyst and is carried out under mild conditions to achieve high yield and selectivity.

What industries use N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide (CAS: 144222-34-4)?

N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide is primarily used in the pharmaceutical industry as a potential therapeutic agent. It also finds applications in the polymer industry as a stabilizer and in the development of sensors due to its reactivity and chemical properties.

What precautions should be taken when handling N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide (CAS: 144222-34-4)?

When handling N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be stored in a cool, dry place away from heat and direct sunlight. In case of a spill, it should be handled carefully using appropriate spill response tools and procedures, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.