2-Bromo-6-fluoropyridine

Basic Information

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CAS Number

144100-07-2

Molecular Formula

C5H3BrFN

Molecular Weight

175.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

32°C

Boiling Point

164°C

Flash Point

74.9℃

Refractive Index

1.532

SMILES

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C1=CC(=NC(=C1)Br)F

InChI

InChI=1S/C5H3BrFN/c6-4-2-1-3-5(7)8-4/h1-3H

InChIKey

ZIDIKYIZXMYHAW-UHFFFAOYSA-N

LogP

1.9831999999999999

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

78.8

Safety Information

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GHS Hazard Pictograms

H301

H311

H332

H315

H319

H335

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H311 Toxic in contact with skin
Acute toxicity, dermal

H332 Harmful if inhaled
Acute toxicity, inhalation

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

2-Bromo-6-fluoropyridine, AldrichCPR
A3119
B3667
FT-0659759
ZIDIKYIZXMYHAW-UHFFFAOYSA-N
InChI=1/C5H3BrFN/c6-4-2-1-3-5(7)8-4/h1-3
SY014349
937379-49-2
AKOS005064102
AC-24935
DTXSID80932219
2-bromo-6-fluoropyridine
BCP14733
FT-0648076
pyridine, 2-bromo-6-fluoro-
2-brom-6-fluorpyridin
Platinum(1+), (2-bromo-5-fluoropyridine-kappaN)(9-hydroxy-6-methylpyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(1H,6H)-dionato-kappaN1,kappaN12)(6-methyl-3-pyridinol-kappaN1)-, (SP-4-2)-, hexafluorophosphate(1-)
SCHEMBL103057
AM20050815
10019-16-6
2-Bromo-6-fluoro-pyridine
6-bromo-2-fluoropyridine
Platinum(1+), (2-bromo-5-fluoropyridine-N)(9-hydroxy-6-methylpyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(1H,6H)-dionato-N1,N12)(6-methyl-3-pyridinol-N1)-, (SP-4-2)-, hexafluorophosphate(1-)
MFCD03095258
A859653
EN300-104427
CS-W003029
PS-8591
144100-07-2
AC-5413
AB13626

MDL Number

MFCD03095258

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Bromo-6-fluoropyridine (CAS: 144100-07-2)?

2-Bromo-6-fluoropyridine is a crystalline solid with a molecular weight of approximately 226.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly with nucleophiles. It can be used as a building block in organic synthesis and as a pharmaceutical intermediate.

How is 2-Bromo-6-fluoropyridine (CAS: 144100-07-2) typically synthesized?

2-Bromo-6-fluoropyridine is typically synthesized through the bromination of 6-fluoropyridine with bromine in the presence of a Lewis acid catalyst like iron(III) bromide. The reaction provides a high yield and good selectivity, making it a robust method for preparing this compound.

What industries use 2-Bromo-6-fluoropyridine (CAS: 144100-07-2)?

2-Bromo-6-fluoropyridine is used in the pharmaceutical industry for the synthesis of certain drugs, and in the chemical industry as an intermediate in the production of other compounds. It may also find applications in polymer chemistry and as a sensitizer in semiconductors.

What precautions should be taken when handling 2-Bromo-6-fluoropyridine (CAS: 144100-07-2)?

When handling 2-Bromo-6-fluoropyridine, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate spill kits, and the substance should be stored in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.